Department of Food Science and Technology, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Hunan Engineering Technology Research Center for Rapeseed Oil Nutrition Health and Deep Development, Changsha 410128, China.
Molecules. 2020 Jul 22;25(15):3314. doi: 10.3390/molecules25153314.
The natural deep eutectic solvent (NADES) is an excellent solvent for insoluble natural products and medicines. Eutectogels formed by gelation of NADESs are interesting materials that deserve attention. In this study, xanthan gum was used as a gelator to gel choline chloride-xylitol with different water contents in virtue of the excellent solubility of choline chloride-xylitol (1:1) to quercetin. We observed that water was critical to the formation of eutectogels. An MTT assay indicated that our eutectogel had excellent biocompatibility as its corresponding hydrogel. According to rheological tests, xanthan gum-based eutectogels had better viscoelastic properties, higher thermal stability, and more defined shear thinning behavior than its corresponding hydrogel. Texture profile analysis showed that eutectogels with less water content had higher hardness and adhesiveness. Meanwhile, Differential scanning calorimeter (DSC) results suggested that the various rheological and texture properties of eutectogels could be attributed to changes in the water state, which was influenced by the hydrogen bonding network of NADES. This biocompatible eutectogel with tunable properties was expected to find applications in novel drug delivery vehicles, which are widely used in the fields of medicine and food.
天然深共晶溶剂 (NADES) 是一种出色的不溶性天然产物和药物溶剂。由 NADES 凝胶化形成的共晶凝胶是一种值得关注的有趣材料。在这项研究中，黄原胶被用作凝胶剂，通过 choline chloride-xylitol（1:1）对槲皮素的优异溶解性，将 choline chloride-xylitol 与不同含水量凝胶化。我们观察到水对共晶凝胶的形成至关重要。MTT 测定表明，我们的共晶凝胶具有优异的生物相容性，与其相应的水凝胶相当。根据流变学测试，基于黄原胶的共晶凝胶具有更好的粘弹性、更高的热稳定性和更明确的剪切稀化行为，优于其相应的水凝胶。质构分析表明，含水量较少的共晶凝胶具有更高的硬度和粘性。同时，差示扫描量热法 (DSC) 结果表明，共晶凝胶的各种流变学和质构特性可归因于水状态的变化，这受 NADES 氢键网络的影响。这种具有可调节性能的生物相容性共晶凝胶有望在新型药物输送载体中得到应用，这些载体广泛应用于医学和食品领域。
