Department of Gynecology, Affiliated Hospital of Zunyi Medical University, No 149, Dalian road, Zunyi City, 563100, Guizhou Province, China.
BMC Cancer. 2020 Jul 25;20(1):691. doi: 10.1186/s12885-020-07191-8.
Previous studies have shown that fibrinogen-to-albumin ratio (FAR) is a novel prognostic immune biomarker in various diseases. In this study, we investigated the role of FAR in the prognosis of patients with stage IB-IIA cervical cancer (CC).
A total of 278 eligible participants with newly diagnosed CC (stage IB-IIA) who had undergone radical hysterectomy followed by adjuvant chemotherapy were enrolled in this study. Demographics, clinicopathological variables, and laboratory tests were obtained from the medical records. Risk factors for overall survival (OS) and recurrence-free survival (RFS) were evaluated by univariate and multivariate Cox proportional regression analyses. The association between OS, RFS, and FAR was assessed by the Kaplan-Meier method using log-rank test.
FAR was associated with age, International Federation of Gynecology and Obstetrics (FIGO) stage, depth of the invasion, and C-reactive protein (CRP) level (P < 0.05). Preoperative FAR was an effective predictor for OS in CC patients with a cut-off value of 7.75 and an area under the curve (AUC) of 0.707 (P < 0.001). The univariate and multivariate Cox analyses indicated that FIGO stage and FAR were two independent risk factors for both OS and RFS (P < 0.05). Kaplan-Meier analysis confirmed that patients with high FAR levels showed significantly lower RFS (P = 0.004) and OS (P = 0.003) than those with low FAR levels.
This study indicated that elevated preoperative FAR might be a novel prognostic factor for CC patients with stage IB-IIA.
先前的研究表明，纤维蛋白原与白蛋白比值（FAR）是各种疾病中一种新的预后免疫生物标志物。在本研究中，我们研究了 FAR 在 IB-IIA 期宫颈癌（CC）患者预后中的作用。
本研究共纳入 278 名接受根治性子宫切除术加辅助化疗的新诊断为 CC（IB-IIA 期）的合格参与者。从病历中获取人口统计学、临床病理变量和实验室检查结果。通过单因素和多因素 Cox 比例回归分析评估总生存（OS）和无复发生存（RFS）的危险因素。通过对数秩检验的 Kaplan-Meier 方法评估 OS、RFS 和 FAR 之间的关系。
FAR 与年龄、国际妇产科联合会（FIGO）分期、浸润深度和 C 反应蛋白（CRP）水平相关（P<0.05）。术前 FAR 是 CC 患者 OS 的有效预测指标，截断值为 7.75，曲线下面积（AUC）为 0.707（P<0.001）。单因素和多因素 Cox 分析表明，FIGO 分期和 FAR 是 OS 和 RFS 的两个独立危险因素（P<0.05）。Kaplan-Meier 分析证实，FAR 水平高的患者 RFS（P=0.004）和 OS（P=0.003）明显低于 FAR 水平低的患者。
本研究表明，术前 FAR 升高可能是 IB-IIA 期 CC 患者的一个新的预后因素。
