Taki Faten, Lopez Katherine, Zupan Bojana, Bergin Paul, Docampo Melissa D, Alves-Bezerra Michele, Toth Judit Gal, Chen Qiuying, Argyropoulos Kimon V, Barboza Luendreo, Pickup Emily, Fancher Nicholas, Hiller Abbi, Gross Steven, Cohen David E, van den Brink Marcel R M, Toth Miklos
Department of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
Psychological Science Department, Vassar College, Poughkeepsie 124 Raymond Avenue, New York, NY 12604, USA.
iScience. 2020 Aug 21;23(8):101357. doi: 10.1016/j.isci.2020.101357. Epub 2020 Jul 10.
Regular physical activity improves physical and mental health. Here we found that the effect of physical activity extends to the next generation. Voluntary wheel running of dams, from postpartum day 2 to weaning, increased the social dominance and reproductive success, but not the physical/metabolic health, of their otherwise sedentary offspring. The individual's own physical activity did not improve dominance status. Maternal exercise did not disrupt maternal care or the maternal and offspring microbiota. Rather, the development of dominance behavior in the offspring of running mothers could be explained by the reduction of LIF, CXCL1, and CXCL2 cytokines in breast milk. These data reveal a cytokine-mediated lactocrine pathway that responds to the mother's postpartum physical activity and programs offspring social dominance. As dominance behaviors are highly relevant to the individual's survival and reproduction, lactocrine programming could be an evolutionary mechanism by which a mother promotes the social rank of her offspring.
规律的体育活动可改善身心健康。我们在此发现，体育活动的影响会延伸至下一代。产后第2天至断奶期间，母鼠自愿进行轮转跑步，这增加了原本久坐不动的后代的社会主导地位和繁殖成功率，但并未改善其身体/代谢健康状况。个体自身的体育活动并未改善其主导地位。母体运动并未扰乱母性照料或母体及后代的微生物群。相反，跑步母鼠后代中支配行为的发展可以通过母乳中白血病抑制因子（LIF）、CXC趋化因子配体1（CXCL1）和CXC趋化因子配体2（CXCL2）细胞因子的减少来解释。这些数据揭示了一种细胞因子介导的泌乳内分泌途径，该途径对母亲产后的体育活动做出反应，并规划后代的社会主导地位。由于支配行为与个体的生存和繁殖高度相关，泌乳内分泌编程可能是一种进化机制，通过这种机制母亲可以提升其后代的社会地位。
