Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Psychopharmacology (Berl). 2020 Nov;237(11):3259-3268. doi: 10.1007/s00213-020-05608-7. Epub 2020 Jul 26.
Previous studies have suggested that chronic cannabis use has been associated with increased blood oxygen level-dependent (BOLD) response during a response inhibition task; however, these studies primarily included males.
We investigated whether gender moderated the effects of cannabis use on BOLD response and behavioral performance during a Go-NoGo task in adolescents and young adults following 2 weeks of monitored abstinence.
Participants included 77 16-26-year olds (MJ = 36, controls = 41). An emotion-based Go-NoGo task required participants to inhibit their response during a calm face. A whole-brain analysis looked at differences between cannabis group, gender, and their interaction.
Significant greater BOLD responses were observed in cannabis users compared with that in controls in the left frontal cortex, left cingulate cortex, and the left thalamus during correct response inhibitions; gender did not moderate these effects.
Supporting previous research, cannabis users showed greater BOLD responses in core areas associated with response inhibition during a Go-NoGo task, even after a minimum of 2 weeks of abstinence.
先前的研究表明，慢性大麻使用与反应抑制任务期间的血氧水平依赖（BOLD）反应增加有关；然而，这些研究主要包括男性。
我们研究了在 2 周的监测禁欲后，青少年和年轻人进行 Go-NoGo 任务时，大麻使用对 BOLD 反应和行为表现的影响是否受性别调节。
参与者包括 77 名 16-26 岁的青少年（MJ=36，对照组=41）。基于情绪的 Go-NoGo 任务要求参与者在平静的面孔时抑制他们的反应。全脑分析观察了大麻组、性别及其相互作用之间的差异。
与对照组相比，大麻使用者在正确反应抑制时，左额皮质、左扣带回和左丘脑的 BOLD 反应明显更高；性别没有调节这些影响。
支持先前的研究，即使在至少 2 周的禁欲后，大麻使用者在 Go-NoGo 任务中与反应抑制相关的核心区域表现出更高的 BOLD 反应。
