Guruaribam Victoria Devi, Sarumathi T
Department of Oral Medicine Diagnosis and Radiology, Sree Balaji Dental College and Hospital, BIHER, Chennai, Tamil Nadu, India.
J Cancer Res Ther. 2020 Apr-Jun;16(3):401-404. doi: 10.4103/jcrt.JCRT_512_19.
To review the relevance of sialic acid as a tumour marker in oral cancer. Tumour marker are useful in the screening for early malignancy. Sialic acids are important in determining the surface properties of cells and has been implicated in cellular invasiveness, adhesiveness, and immunogenicity. Sialic acids are commonly found at the outermost end of glycan chains of all cell types. Increase in the levels of sialic acid in oral cancer indicates its importance as a tumour marker.Both serum and salivary sialic acid levels can be used as a screening tool and a diagnostic aid for oral cancer. Salivary sialic acid can be used as a non-invasive, cost effective and reliable diagnostic methods for screening and monitoring of oral cancer. In patients with oral cancer, glycoprotein metabolism is altered. Increase in the levels of sialic acid in oral cancer indicate its importance as a tumour marker. Changes in the serum is reflected in saliva. Salivary sialic acid can be used as non-invasive, cost effective and reliable diagnostic methods for screening and monitoring of oral cancer. Early the diagnosis, better the prognosis.
综述唾液酸作为口腔癌肿瘤标志物的相关性。肿瘤标志物在早期恶性肿瘤筛查中很有用。唾液酸在决定细胞表面特性方面很重要，并且与细胞侵袭性、黏附性和免疫原性有关。唾液酸普遍存在于所有细胞类型聚糖链的最末端。口腔癌中唾液酸水平的升高表明其作为肿瘤标志物的重要性。血清和唾液中的唾液酸水平都可以用作口腔癌的筛查工具和诊断辅助手段。唾液酸可作为一种用于口腔癌筛查和监测的非侵入性、经济高效且可靠的诊断方法。在口腔癌患者中，糖蛋白代谢会发生改变。口腔癌中唾液酸水平的升高表明其作为肿瘤标志物的重要性。血清中的变化会反映在唾液中。唾液酸可作为一种用于口腔癌筛查和监测的非侵入性、经济高效且可靠的诊断方法。诊断越早，预后越好。
