Chen Pengyu, Ding Feng, Cai Rong, Javed Ibrahim, Yang Wen, Zhang Zhenzhen, Li Yuhuan, Davis Thomas P, Ke Pu Chun, Chen Chunying
Materials Research and Education Center, Auburn University, Auburn, AL 36849, United States.
Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, United States.
Nano Today. 2020 Dec;35. doi: 10.1016/j.nantod.2020.100937. Epub 2020 Jul 22.
The protein corona has served as a central dogma and a nuisance to the applications of nanomedicine and nanobiotechnology for well over a decade. Here we introduce the emerging field of amyloidosis inhibition, which aims to understand and harness the interfacial phenomena associated with a nanoparticle interacting with pathogenic amyloid proteins. Much of this interaction correlates with our understanding of the protein corona, and yet much differs, as elaborated for the first time in this . Specifically, we examine the , and features of the new class of "amyloid protein corona", and discuss how the interactions with nanoparticles may halt the self-assembly of amyloid proteins. As amyloidosis is driven off pathway by the nanoparticles, the oligomeric and protofibrillar populations are suppressed to ameliorate their cytotoxicity. Furthermore, as amyloid proteins spread via the transport of bodily fluids or cross seeding, amyloidosis is inherently associated with dynamic proteins and ligands to evoke the immune system. Accordingly, we ponder the structural and medical implications of the amyloid protein corona in the presence of their stimulated cytokines. Understanding and exploiting the amyloid protein corona may facilitate the development of new theranostics against a range of debilitating amyloid diseases.
十多年来，蛋白质冠层一直是纳米医学和纳米生物技术应用的核心教条和麻烦。在此，我们介绍淀粉样变性抑制这一新兴领域，其旨在理解和利用与纳米颗粒与致病性淀粉样蛋白相互作用相关的界面现象。这种相互作用的许多方面与我们对蛋白质冠层的理解相关，但也有许多不同之处，正如本文首次阐述的那样。具体而言，我们研究了新型“淀粉样蛋白冠层”的 、 和 特征，并讨论了与纳米颗粒的相互作用如何可能阻止淀粉样蛋白的自组装。由于纳米颗粒使淀粉样变性偏离正常途径，寡聚体和原纤维群体受到抑制，从而减轻其细胞毒性。此外，由于淀粉样蛋白通过体液运输或交叉播种传播，淀粉样变性与动态蛋白质和配体固有地相关，以激发免疫系统。因此，我们思考了在受刺激的细胞因子存在下淀粉样蛋白冠层的结构和医学意义。理解和利用淀粉样蛋白冠层可能有助于开发针对一系列使人衰弱的淀粉样疾病的新型治疗诊断方法。
