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2020 年德国莱茵兰-普法尔茨州居家隔离的 COVID-19 患者中 SARS-CoV-2 RNA 检测持续时间:区间 censored 生存分析。

Duration of SARS-CoV-2 RNA detection in COVID-19 patients in home isolation, Rhineland-Palatinate, Germany, 2020 - an interval-censored survival analysis.

机构信息

District Public Health Authority, Montabaur, Germany.

District Public Health Authority, Trier, Germany.

出版信息

Euro Surveill. 2020 Jul;25(30). doi: 10.2807/1560-7917.ES.2020.25.30.2001292.

DOI:10.2807/1560-7917.ES.2020.25.30.2001292
PMID:32734855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7393848/
Abstract

We analysed consecutive RT-qPCR results of 537 symptomatic coronavirus disease (COVID-19) patients in home quarantine. Respectively 2, 3, and 4 weeks after symptom onset, 50%, 25% and 10% of patients had detectable RNA from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In patients with mild COVID-19, RNA detection is likely to outlast currently known periods of infectiousness by far and fixed time periods seem more appropriate in determining the length of home isolation than laboratory-based approaches.

摘要

我们分析了 537 例在家隔离的有症状的冠状病毒病(COVID-19)患者的连续 RT-qPCR 结果。分别在症状出现后 2、3 和 4 周,50%、25%和 10%的患者可检测到严重急性呼吸综合征冠状病毒-2(SARS-CoV-2)的 RNA。在轻症 COVID-19 患者中,RNA 检测可能远远超过目前已知的传染性期,并且与基于实验室的方法相比,固定时间段似乎更适合确定居家隔离的时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9858/7393848/a3cc218ec0f1/2001292-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9858/7393848/d46db05ee1f8/2001292-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9858/7393848/a3cc218ec0f1/2001292-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9858/7393848/d46db05ee1f8/2001292-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9858/7393848/a3cc218ec0f1/2001292-f2.jpg

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