Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Inflammation. 2020 Dec;43(6):2372-2378. doi: 10.1007/s10753-020-01306-w.
Nonalcoholic fatty liver disease (NAFLD) has become a major health concern worldwide. The aim of this study was to investigate the effect and mechanism of electroacupuncture (EA) on nonalcoholic fatty liver disease (NAFLD) in rats induced by high-fat diet (HFD). A model of nonalcoholic fatty liver in rats induced by high fat was established. Rats in the control group were fed standard diet. The rats in model group and EA group were fed with HFD. From the fifth week, the rats in EA group were treated with EA ("FengLongXue," "YinLingQuanXue," "SanYinJiaoXue") for 2 weeks respectively. EA could significantly reduce serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum triglyceride (TG), serum cholesterol (TC), and serum cytokines, and improve liver histopathological changes in rats. EA also could regulate the levels of Sirt1/NF-κB pathway in rat liver. EA relieved liver injury in NAFLD rats, and its mechanism may be related to the regulation of Sirt1/NF-κB pathway in rats. This is the first report that electroacupuncture alleviates liver inflammatory reaction of nonalcoholic fatty liver by enhancing Sirt1 expression and inhibiting NLRP3/NF-kB signal pathway.
非酒精性脂肪性肝病（NAFLD）已成为全球范围内的主要健康问题。本研究旨在探讨电针对高脂饮食（HFD）诱导的大鼠非酒精性脂肪性肝病（NAFLD）的作用及其机制。建立了高脂诱导的大鼠非酒精性脂肪性肝病模型。对照组大鼠给予标准饮食。模型组和电针组大鼠给予 HFD。从第 5 周开始，电针组大鼠分别接受电针（“丰隆穴”、“阴陵泉穴”、“三阴交穴”）治疗 2 周。电针可显著降低血清丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、血清甘油三酯（TG）、血清胆固醇（TC）和血清细胞因子水平，改善大鼠肝组织病理变化。电针还可以调节大鼠肝组织中 Sirt1/NF-κB 通路的水平。电针减轻了 NAFLD 大鼠的肝损伤，其机制可能与调节大鼠 Sirt1/NF-κB 通路有关。这是首次报道电针通过增强 Sirt1 表达和抑制 NLRP3/NF-κB 信号通路来减轻非酒精性脂肪性肝病大鼠的肝炎症反应。
