Biodonostia Health Research Institute, Group of Cellular Oncology, San Sebastian, Spain.
Pathology Department, Donostia University Hospital, San Sebastian, Spain.
Aging Cell. 2020 Sep;19(9):e13198. doi: 10.1111/acel.13198. Epub 2020 Aug 1.
Age-related cognitive decline and neurodegenerative diseases are associated with less functional neurogenic niches. It has been recently shown that aged subventricular zone (SVZ) suffers an infiltration of T cells, which affects neural stem cell activity in mice. Whether this occurs in human neurogenic niches or to which extent T-cell infiltration is also taking place in neurodegenerative diseases remains unknown. In this work, we studied the presence of T cells in both human neurogenic niches in young and old individuals. There was a significant increase in the number of CD3 and CD8 T cells in the SVZ of elderly individuals, which was not detected in the dentate gyrus. Moreover, we also found CD3 and CD8 T cells in the SVZ of individuals with neurodegenerative diseases. However, T-cell count was similar when compared non-neuropathological elderly with disease diagnosed patients. Our study reveals the infiltration of T cells in old human brains, particularly in the SVZ under non-pathological conditions and also in neurodegenerative contexts.
与年龄相关的认知能力下降和神经退行性疾病与功能神经发生龛减少有关。最近的研究表明，衰老的侧脑室下区 (SVZ) 会受到 T 细胞的浸润，这会影响小鼠神经干细胞的活性。这种情况是否发生在人类神经发生龛中，或者 T 细胞浸润在神经退行性疾病中发生到何种程度，目前尚不清楚。在这项工作中，我们研究了年轻和老年个体的人类神经发生龛中 T 细胞的存在。老年人 SVZ 中的 CD3 和 CD8 T 细胞数量显著增加，而在齿状回中未检测到。此外，我们还在神经退行性疾病患者的 SVZ 中发现了 CD3 和 CD8 T 细胞。然而，与非神经病理学老年人相比，疾病诊断患者的 T 细胞计数相似。我们的研究揭示了 T 细胞在老年人大脑中的浸润，特别是在 SVZ 中，这种浸润在非病理条件下以及神经退行性疾病中都存在。
