Alatyyat Shumukh M, Alasmari Houton M, Aleid Omamah A, Abdel-Maksoud Mohamed S, Elsherbiny Nehal
Pharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Department of Pharmacology & Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Tissue Cell. 2020 Aug;65:101351. doi: 10.1016/j.tice.2020.101351. Epub 2020 Mar 19.
Stem cells have currently gained attention in the field of medicine not only due to their ability to repair dysfunctional or damaged cells, but also they could be used as drug delivery system after being engineered to do so. Human umbilical cord is attractive source for autologous and allogenic stem cells that are currently amenable to treatment of various diseases. Human umbilical cord stem cells are -in contrast to embryonic and fetal stem cells- ethically noncontroversial, inexpensive and readily available source of cells. Umbilical cord, umbilical cord vein, amnion/placenta and Wharton's jelly are all rich of many types of multipotent stem cell populations capable of forming many different cell types. This review will focus on umbilical cord stem cells processing and current application in medicine.
目前，干细胞在医学领域备受关注，这不仅是因为它们具有修复功能失调或受损细胞的能力，还在于经过工程改造后可被用作药物递送系统。人脐带是自体和异体干细胞的一个有吸引力的来源，目前可用于治疗各种疾病。与胚胎干细胞和胎儿干细胞相比，人脐带干细胞在伦理上没有争议，是一种廉价且易于获取的细胞来源。脐带、脐静脉、羊膜/胎盘和华通氏胶都富含多种多能干细胞群体，能够形成许多不同的细胞类型。本综述将聚焦于脐带干细胞的处理及其在医学中的当前应用。
