Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, 14395-1561, Iran.
School of Biology, College of Sciences, University of Tehran, Tehran, 1417614411, Iran.
Stem Cell Res Ther. 2024 Jul 9;15(1):205. doi: 10.1186/s13287-024-03784-3.
Vascular tissue engineering is a promising approach for regenerating damaged blood vessels and developing new therapeutic approaches for heart disease treatment. To date, different sources of cells have been recognized that offer assistance within the recovery of heart supply routes and veins with distinctive capacities and are compelling for heart regeneration. However, some challenges still remain that need to be overcome to establish the full potential application of these cells. In this paper, we review the different cell sources used for vascular tissue engineering, focusing on extraembryonic tissue-derived cells (ESCs), and elucidate their roles in cardiovascular disease. In addition, we highlight the intricate interplay between mechanical and biochemical factors in regulating mesenchymal stem cell (MSC) differentiation, offering insights into optimizing their application in vascular tissues.
血管组织工程是一种有前途的方法，可以用于再生受损的血管，并为心脏病治疗开发新的治疗方法。迄今为止，已经认识到不同来源的细胞可以在恢复心脏供应途径和静脉方面提供帮助，这些细胞具有不同的能力，对于心脏再生具有吸引力。然而，仍然存在一些需要克服的挑战，才能充分发挥这些细胞的应用潜力。本文综述了用于血管组织工程的不同细胞来源，重点介绍了胚外组织来源的细胞（ESCs），并阐明了它们在心血管疾病中的作用。此外，我们还强调了机械和生化因素在调节间充质干细胞（MSC）分化中的复杂相互作用，为优化其在血管组织中的应用提供了思路。
