Pasanen P A, Kauppinen R, Eskelinen M J, Partanen K P, Pikkarainen P H, Alhava E M
Department of Surgery, Kuopio University Hospital, Finland.
J Cancer Res Clin Oncol. 1993;119(10):622-6. doi: 10.1007/BF01372726.
The sera of 51 patients with malignant (n = 25) and benign (n = 26) hepatopancreatobiliary disorders were analysed by 1H magnetic resonance spectroscopy (NMR) in order to distinguish between malignant and benign diseases causing jaundice and/or cholestasis. Macromolecular linewidths were determined both manually and automatically with a computed analysis, and both methylene (CH2) and methyl (CH3) resonances were evaluated. The mean linewidth of the CH3 peak was significantly narrower in the patients with malignant disease than in the patients with benign disease both in the manual and computed analyses, but no significant differences in the CH2 peak were detected. Diagnostic sensitivity and specificity of the CH3 peak determined in the computed analysis were 92% and 27% respectively. In the light of the current study, it seems obvious that because overlap between benign and malignant groups was too great, 1H NMR spectroscopy of plasma is not of practical value in distinguishing between benign and malignant causes of jaundice and/or cholestasis.
为了区分导致黄疸和/或胆汁淤积的恶性和良性疾病，我们对51例患有恶性（n = 25）和良性（n = 26）肝胰胆疾病患者的血清进行了氢核磁共振波谱分析（NMR）。通过手动和计算机分析确定大分子线宽，并评估亚甲基（CH2）和甲基（CH3）共振。在手动和计算机分析中，患有恶性疾病的患者的CH3峰平均线宽均明显窄于患有良性疾病的患者，但未检测到CH2峰有显著差异。计算机分析中确定的CH3峰的诊断敏感性和特异性分别为92%和27%。根据当前研究，由于良性和恶性组之间的重叠太大，血浆的氢核磁共振波谱在区分黄疸和/或胆汁淤积的良性和恶性原因方面似乎没有实际价值，这一点似乎很明显。
