Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Center for Vaccine Innovation and Access, PATH, Seattle, Washington, United States.
Vaccine. 2020 Sep 11;38(40):6199-6204. doi: 10.1016/j.vaccine.2020.07.050. Epub 2020 Aug 1.
Routine maternal immunisation against influenza and pertussis are recommended by the WHO to protect mother and child, and new vaccines are under development. Introducing maternal vaccines into national programmes requires an understanding of vaccine delivery costs - particularly in low resource settings.
We searched Medline, Embase, Econlit, and Global Health for studies reporting costs of delivering vaccination during pregnancy but excluded studies that did not separate the vaccine purchase price. Extracted costs were inflated and converted to 2018 US dollars.
Sixteen studies were included, of which two used primary data to estimate vaccine delivery costs. Costs per dose ranged from $0.55 to $0.64 in low-income countries, from $1.25 to $6.55 for middle-income countries, and from $5.76 to $39.87 in high-income countries.
More research is needed on the costs of delivering maternal immunisation during pregnancy, and of integrating vaccine delivery into existing programmes of antenatal care especially in low and middle-income countries.
世界卫生组织建议常规为产妇接种流感和百日咳疫苗，以保护母婴健康，同时也在开发新的疫苗。在引入产妇疫苗纳入国家计划时，需要了解疫苗接种成本 - 特别是在资源有限的环境中。
我们在 Medline、Embase、Econlit 和 Global Health 中搜索了报告妊娠期疫苗接种成本的研究，但排除了未单独列出疫苗采购价格的研究。提取的成本进行了通胀调整，并转换为 2018 年美元。
共纳入 16 项研究，其中 2 项研究使用原始数据估算了疫苗接种成本。在低收入国家，每剂疫苗的成本为 0.55 美元至 0.64 美元，中等收入国家为 1.25 美元至 6.55 美元，高收入国家为 5.76 美元至 39.87 美元。
需要对妊娠期产妇免疫接种的疫苗接种成本以及将疫苗接种纳入现有的产前护理计划进行更多研究，特别是在低收入和中等收入国家。
