School of Medical Science, Griffith University, Southport, QLD 4215, Australia.
Menzies Health Institute Queensland, Griffith University, Southport, QLD 4215, Australia.
Mar Drugs. 2020 Aug 4;18(8):412. doi: 10.3390/md18080412.
Nutritional strategies to help promote immune competence are of particular interest for a range of population groups. This study aimed to assess the potential impacts of fucoidan, a seaweed-derived bioactive polysaccharide, on gut markers of immunity and inflammation. A group of professional team-sport athletes were selected for inclusion in the study given the recognized potential for intense physical activity to induce alterations in immune function. A retrospective analysis was performed on stored fecal samples which had been collected from professional team-sport athletes ( = 22) and healthy adults ( = 11) before and after seven days of supplementation with fucoidan (/ extract, 1 g/d). Fecal concentrations of calprotectin, secretory immunoglobulin A (sIgA) and lysozyme were determined using enzyme-linked immunosorbent assays. The supplement was well tolerated by participants with no adverse events reported. At baseline, fecal lysozyme concentrations were 73% higher in the healthy adults compared to the professional athletes ( = 0.001). For the professional athletes, a significant (45%) increase in fecal lysozyme was observed following the supplementation period ( = 0.001). These data suggest that fucoidan supplementation may have the potential to promote the secretion of antimicrobial peptides in specific population groups and contribute to the regulation of mucosal immune health.
营养策略有助于提高免疫力，这对于一系列人群来说特别重要。本研究旨在评估褐藻糖胶（一种源自海藻的生物活性多糖）对肠道免疫和炎症标志物的潜在影响。鉴于剧烈的体育活动可能会改变免疫功能，研究选择了一组专业的团队运动运动员来参与研究。对存储的粪便样本进行了回顾性分析，这些样本是在补充褐藻糖胶（/提取物，1 克/天）前后从专业团队运动运动员（=22）和健康成年人（=11）中收集的。使用酶联免疫吸附试验测定粪便中钙卫蛋白、分泌型免疫球蛋白 A（sIgA）和溶菌酶的浓度。参与者对补充剂的耐受性良好，没有报告不良反应。在基线时，健康成年人的粪便溶菌酶浓度比专业运动员高约 73%（=0.001）。对于专业运动员，补充后粪便溶菌酶显著增加（~45%）（=0.001）。这些数据表明，褐藻糖胶补充剂可能具有促进特定人群分泌抗菌肽的潜力，并有助于调节黏膜免疫健康。
