Department of Clinical Data Center, The Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
The Guangdong Provincial Children's Medical Research Center, Guangzhou, China.
PLoS Negl Trop Dis. 2020 Aug 6;14(8):e0008472. doi: 10.1371/journal.pntd.0008472. eCollection 2020 Aug.
In order to rapidly inform polices in the international response to the ongoing pandemic of coronavirus disease 19 (COVID-19), we summarize in this review current evidence on epidemiological and clinical features of the infection, transmission routes, problems of nucleic-acid testing, the epidemiological trend in China and impact of interventional measures, and some lessons learned. We concluded that the epidemic is containable with traditional nonpharmacological interventions, mainly through social distancing and finding and isolating suspected patients and close contacts. Nonpharmacological interventions are the only effective measures currently accessible and have suppressed some 90% of the infections in China. Close contacts are the major mechanism of transmission, which makes it possible to control this epidemic through nonpharmacological methods. Nucleic-acid testing alone may miss some 50% of infected patients, and other methods such as chest computerized tomography (CT) or serology should be considered to supplement molecular testing. The development of vaccines and drugs is important, but hesitation to make use of nonpharmacological interventions may mean missing golden opportunities for effective actions.
为了快速为国际上应对 2019 冠状病毒病（COVID-19）大流行的政策提供信息，我们在此综述了目前关于该感染的流行病学和临床特征、传播途径、核酸检测问题、中国的流行病学趋势和干预措施的影响，以及一些经验教训。我们的结论是，通过传统的非药物干预措施，主要是通过社会隔离以及发现和隔离疑似患者和密切接触者，该疫情是可以控制的。非药物干预措施是目前唯一可行的有效措施，已在中国抑制了约 90%的感染。密切接触是主要的传播机制，这使得通过非药物方法控制该流行病成为可能。单独进行核酸检测可能会漏诊约 50%的感染患者，因此应考虑使用胸部计算机断层扫描（CT）或血清学等其他方法来补充分子检测。疫苗和药物的研发很重要，但对非药物干预措施的犹豫不决可能意味着错失采取有效行动的黄金机会。
