Shahin Hady, Elmasry Moustafa, Steinvall Ingrid, Söberg Folke, El-Serafi Ahmed
Department of Hand Surgery and Plastic Surgery and Burns, Linköping University Hospital, 581 85, Linköping, Östergötland, Sweden.
The Department of Biomedical and Clinical Sciences, Linköping University, Linköping University Hospital, 581 83, Linköping, Östergötland, Sweden.
Burns Trauma. 2020 Aug 3;8:tkaa022. doi: 10.1093/burnst/tkaa022. eCollection 2020.
Skin regeneration represents a promising line of management for patients with skin loss, including burn victims. The current approach of spraying single cells over the defective areas results in variable success rates in different centers. The modern approach is to synthesize a multilayer skin construct that is based on autologous stem cells. One of the main complications with different types of transplants is sloughing due to the absence of proper vascularization. Ensuring proper vascularization will be crucial for the integration of skin constructs with the surrounding tissues. Combination of the right cells with scaffolds of proper physico-chemical properties, vascularization can be markedly enhanced. The material effect, pore size and adsorption of certain proteins, as well as the application of appropriate growth factors, such as vascular endothelial growth factors, can have an additive effect. A selection of the most effective protocols is discussed in this review.
皮肤再生是皮肤缺损患者（包括烧伤患者）一种很有前景的治疗方法。目前在缺损区域喷洒单细胞的方法在不同中心的成功率各不相同。现代方法是合成一种基于自体干细胞的多层皮肤构建体。不同类型移植的主要并发症之一是由于缺乏适当的血管化而导致脱落。确保适当的血管化对于皮肤构建体与周围组织的整合至关重要。将合适的细胞与具有适当物理化学性质的支架相结合，可以显著增强血管化。材料效应、孔径和某些蛋白质的吸附，以及应用适当的生长因子，如血管内皮生长因子，都可以产生累加效应。本综述讨论了最有效方案的选择。
