Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
National Defense Medical Center, Taipei, Taiwan.
J Formos Med Assoc. 2021 Jan;120(1 Pt 3):713-719. doi: 10.1016/j.jfma.2020.07.033. Epub 2020 Jul 29.
Coronavirus disease-2019 (COVID-19) is a worldwide pandemic. We present the clinical characteristics and outcomes of 28 COVID-19 patients treated in our hospital in Taiwan.
Patients with COVID-19, confirmed by positive real-time reverse-transcriptase polymerase chain reaction results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral nucleic acids from oropharyngeal swab specimens between February 4, 2020 and July 6, 2020, were enrolled. Their clinical characteristics and outcomes were reviewed.
Seventeen of the 28 patients (60.7%) had pneumonia. The most frequent symptoms were cough (n = 23, 82.1%) and fever (n = 17, 60.7%). The development of pneumonia was associated with age ≥40 years (p < 0.024), body mass index (BMI) ≥25 kg/m (p = 0.014), fever (p = 0.007), shortness of breath (p = 0.036), chills ((p = 0.047), and lower platelet counts (<200,000/μL) (p = 0.007). Increased quarantine duration was associated with age ≥40 years (p = 0.026), Charlson index ≥1 (p = 0.037), lower lymphocyte (<1500/uL; p = 0.028) or platelet counts (<200,000/μL) (p = 0.016), lower serum sodium (<140 mEq/L; p = 0.006), and higher C-reactive protein (CRP) level (≥1 mg/dl; p = 0.04). Treatment with hydroxychloroquine or in combination with other medicines did not reduce the quarantine duration. All 28 patients recovered with a median quarantine duration of 27.2 days.
COVID-19 patients with older age, higher BMI, fever, chills or shortness of breath, lower serum sodium level, lower platelet or lymphocyte count, and higher CRP level may be associated with developing pneumonia or longer quarantine duration.
2019 年冠状病毒病（COVID-19）是一种全球性大流行疾病。我们呈现了 28 例在台湾我院接受治疗的 COVID-19 患者的临床特征和结局。
2020 年 2 月 4 日至 2020 年 7 月 6 日期间，我们对经实时逆转录聚合酶链反应（RT-PCR）检测到的新型冠状病毒 2（SARS-CoV-2）呼吸道咽拭子标本的病毒核酸呈阳性的 COVID-19 患者进行了研究。我们回顾了他们的临床特征和结局。
28 例患者中，17 例（60.7%）患有肺炎。最常见的症状为咳嗽（n=23，82.1%）和发热（n=17，60.7%）。肺炎的发生与年龄≥40 岁（p<0.024）、体质量指数（BMI）≥25kg/m（p=0.014）、发热（p=0.007）、呼吸急促（p=0.036）、寒战（p=0.047）和血小板计数<200,000/μL（p=0.007）相关。隔离时间延长与年龄≥40 岁（p=0.026）、Charlson 指数≥1（p=0.037）、淋巴细胞计数<1500/μL（p=0.028）或血小板计数<200,000/μL（p=0.016）、血清钠浓度<140 mEq/L（p=0.006）和 C 反应蛋白（CRP）水平升高（≥1mg/dl；p=0.04）相关。羟氯喹治疗或联合其他药物治疗并未缩短隔离时间。28 例患者全部康复，平均隔离时间为 27.2 天。
年龄较大、BMI 较高、发热、寒战或呼吸急促、血清钠水平较低、血小板计数或淋巴细胞计数较低以及 CRP 水平较高的 COVID-19 患者可能与肺炎或隔离时间延长相关。
