较高的趾甲硒含量与杂食者胰岛素抵抗风险增加有关，但与素食者无关。
Higher toenail selenium is associated with increased insulin resistance risk in omnivores, but not in vegetarians.
作者信息
Gu Qiuyun, Cui Xueying, Du Kun, Wang Bian, Cai Wei, Tang Qingya, Shen Xiuhua
机构信息
Department of Nutrition, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Laboratory Medicine, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
Nutr Metab (Lond). 2020 Aug 3;17:62. doi: 10.1186/s12986-020-00484-6. eCollection 2020.
BACKGROUND
The relationship between selenium (Se) and insulin resistance remains unclear. We aim to explore the association between toenail Se levels and insulin resistance through a cross-sectional study comprising Chinese vegetarians and matched omnivores.
METHODS
In this study, we enrolled 220 vegetarians and 220 omnivores matched by age and sex from Shanghai. The inductively coupled plasma mass spectrometry method was used to measure toenail Se levels. Dietary Se intakes were assessed by the 24-h dietary recall method. Blood samples were collected to measure fasting blood glucose level and fasting insulin concentrations. Insulin resistance index (HOMA-IR) and insulin secretion index (HOMA-B) were calculated to evaluate insulin resistance. Multi-linear regression analysis was performed to determine the association between toenail Se levels and insulin resistance, after adjusting for confounders.
RESULTS
The mean ages of vegetarians (76 vegans, 144 lacto-ovo-vegetarians) and omnivores were 35.96 ± 8.73 years and 35.23 ± 8.93 years, respectively. Of these, 180 (81.8%) were female and 40 (18.2%) were male. No association was found between toenail Se levels and insulin resistance in vegetarians. However, the concentration of Se in toenails was positively correlated with fasting insulin levels ( = 1.030, 95%: 0.393 to 1.667) and HOMA-IR ( = 0.245, 95%: 0.098 to 0.392) in omnivores, after multivariate adjustment for age, sex, BMI, alcohol consumption, income, and daily dietary intakes (energy, protein, fat, carbohydrate, and fiber). This positive relationship persisted only in omnivores whose dietary Se intake was above 60 μg/d.
CONCLUSIONS
Higher toenail Se levels were associated with increased insulin resistance risk in Chinese omnivores whose dietary Se intake was above 60 μg/d, but not in vegetarians. These findings create awareness on the association of dietary Se intake above 60 μg/d with the risk of insulin resistance.
背景
硒（Se）与胰岛素抵抗之间的关系尚不清楚。我们旨在通过一项包含中国素食者和匹配的杂食者的横断面研究，探讨 toenail 硒水平与胰岛素抵抗之间的关联。
方法
在本研究中，我们从上海招募了 220 名素食者和 220 名年龄和性别匹配的杂食者。采用电感耦合等离子体质谱法测量 toenail 硒水平。通过 24 小时饮食回顾法评估膳食硒摄入量。采集血样以测量空腹血糖水平和空腹胰岛素浓度。计算胰岛素抵抗指数（HOMA-IR）和胰岛素分泌指数（HOMA-B）以评估胰岛素抵抗。在调整混杂因素后，进行多线性回归分析以确定 toenail 硒水平与胰岛素抵抗之间的关联。
结果
素食者（76 名纯素食者，144 名蛋奶素食者）和杂食者的平均年龄分别为 35.96±8.73 岁和 35.23±8.93 岁。其中，180 名（81.8%）为女性，40 名（18.2%）为男性。在素食者中，未发现 toenail 硒水平与胰岛素抵抗之间存在关联。然而，在对年龄、性别、BMI、饮酒、收入和每日膳食摄入量（能量、蛋白质、脂肪、碳水化合物和纤维）进行多变量调整后，杂食者的 toenail 硒浓度与空腹胰岛素水平（β = 1.030，95%置信区间：0.393 至 1.667）和 HOMA-IR（β = 0.245，95%置信区间：0.098 至 0.392）呈正相关。这种正相关仅在膳食硒摄入量高于 60μg/d 的杂食者中持续存在。
结论
对于膳食硒摄入量高于 60μg/d 的中国杂食者，较高的 toenail 硒水平与胰岛素抵抗风险增加相关，但在素食者中并非如此。这些发现提高了人们对膳食硒摄入量高于 60μg/d 与胰岛素抵抗风险之间关联的认识。
Zotero 插件