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1例携带意义不明的KCNH2变异体的患者由甲型H1N1流感病毒诱发尖端扭转型室速电风暴

Torsades De Pointes Electrical Storm Induced by H1N1 in a Patient with KCNH2 Variant of Unknown Significance.

作者信息

Khiatah Bashar, Dukes Jonathan, Desai Christina, Frugoli Amanda

机构信息

Department of Internal Medicine, Community Memorial Hospital, 147 N Brent St, Ventura, CA 93003, USA.

Electrophysiology, Cardiology Associate Medical Group, USA.

出版信息

Case Rep Cardiol. 2020 Jul 23;2020:8889769. doi: 10.1155/2020/8889769. eCollection 2020.

DOI:10.1155/2020/8889769
PMID:32774932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7395991/
Abstract

This report describes a case of an electrical storm of Torsades De Pointes in a structurally normal heart, following an H1N1 infection in the presence of a genetic variant of unknown significance. The patient was successfully treated with isoproterenol. This case highlights the dilemma of evaluating novel genetic testing results in a clinical setting.

摘要

本报告描述了一例在结构正常的心脏中发生尖端扭转型室速电风暴的病例，该病例发生在甲型H1N1感染后，同时存在一种意义不明的基因变异。患者通过异丙肾上腺素成功治愈。该病例凸显了在临床环境中评估新型基因检测结果时所面临的困境。

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Torsades De Pointes Electrical Storm Induced by H1N1 in a Patient with KCNH2 Variant of Unknown Significance.1例携带意义不明的KCNH2变异体的患者由甲型H1N1流感病毒诱发尖端扭转型室速电风暴
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本文引用的文献

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Decoding KCNH2 variants of unknown significance.解读意义不明的KCNH2基因变异体。
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Propranolol Versus Metoprolol for Treatment of Electrical Storm in Patients With Implantable Cardioverter-Defibrillator.
普萘洛尔与美托洛尔治疗植入型心律转复除颤器患者电风暴
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The use of antiviral drugs for influenza: Guidance for practitioners 2012/2013.《2012/2013 年度流感抗病毒药物使用指南：临床医师实用手册》
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Electrical storm in idiopathic ventricular fibrillation is associated with early repolarization.特发性室颤中的电风暴与早期复极有关。
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Endo-epicardial homogenization of the scar versus limited substrate ablation for the treatment of electrical storms in patients with ischemic cardiomyopathy.心外膜与心内膜消融治疗缺血性心肌病伴电风暴患者的瘢痕电均化与局限性基质消融。
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Drug-refractory ventricular tachycardias after myocarditis: endocardial and epicardial radiofrequency catheter ablation.心肌炎后药物难治性室性心动过速：心内膜和心外膜射频导管消融。
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Part 8: adult advanced cardiovascular life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.第八部分：成人高级心血管生命支持：2010 年美国心脏协会心肺复苏和紧急心血管急救指南。
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Electrical storm induced by H1N1 A influenza infection.甲型 H1N1 流感感染引发的电风暴。
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Excellent long-term reproducibility of the electrophysiologic efficacy of quinidine in patients with idiopathic ventricular fibrillation and Brugada syndrome.奎尼丁对特发性室颤和Brugada综合征患者电生理疗效具有出色的长期可重复性。
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