Department of Physiotherapy, Faculty of Health Science, University ofMálaga. Biomedical Research Institute of Malaga (IBIMA), Clinimetric Group FE-14, Málaga, Spain. Av/ Arquitecto Peñalosa s/n (Teatinos Campus Expansion), 29071, Malaga, Spain.
Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London, UK.
BMC Geriatr. 2020 Aug 10;20(1):282. doi: 10.1186/s12877-020-01678-6.
Patients with mild cognitive impairment (MCI) experience alterations of functional parameters, such as an impaired balance or gait. The current systematic review set out to investigate whether functional objective performance may predict a future risk of MCI; to compare functional objective parameters in patients with MCI and a control group; and to assess changes in these parameters after different physical activity interventions.
Electronic databases, including PubMed, AMED, CINAHL, EMBASE, PEDro and Web of Science as well as grey literature databases, were searched from inception to February 2020. Cohort studies and Randomized Controlled Trials (RCTs) were included. The risk of bias of the included studies was assessed independently by reviewers using quality assessment checklists. The level of evidence per outcome was assessed using the GRADE criteria.
Seventeen studies met inclusion criteria including patients with MCI. Results from RCTs suggested that gait speed, gait variability and balance may be improved by different physical activity interventions. Cohort studies showed that slower gait speed, above all, under Dual Task (DT) conditions, was the main impaired parameter in patients with MCI in comparison with a Control Gorup. Furthermore, cohort studies suggested that gait variability could predict an incident MCI. Although most of included cohort studies reported low risk of bias, RCTs showed an unclear risk of bias.
Studies suggest that gait variability may predict an incident MCI. Moreover, different gait parameters, above all under DT conditions, could be impaired in patients with MCI. These parameters could be improved by some physical activity interventions. Although cohort studies reported low risk of bias, RCTs showed an unclear risk of bias and GRADE criteria showed a low level of evidence per outcome, so further studies are required to refute our findings.
CRD42019119180.
轻度认知障碍 (MCI) 患者的功能参数会发生改变，例如平衡或步态受损。本系统评价旨在研究功能客观表现是否可预测未来发生 MCI 的风险；比较 MCI 患者和对照组的功能客观参数；并评估不同身体活动干预后这些参数的变化。
从建库到 2020 年 2 月，我们检索了电子数据库，包括 PubMed、AMED、CINAHL、EMBASE、PEDro 和 Web of Science 以及灰色文献数据库。纳入了队列研究和随机对照试验 (RCT)。使用质量评估清单由评审员独立评估纳入研究的偏倚风险。使用 GRADE 标准评估每个结局的证据水平。
纳入了 17 项包括 MCI 患者的研究。RCT 的结果表明，不同的身体活动干预可能会改善步态速度、步态变异性和平衡。队列研究表明，与对照组相比，MCI 患者的主要受损参数是步态速度更慢，尤其是在双重任务 (DT) 条件下。此外，队列研究表明步态变异性可能预测发生 MCI。尽管大多数纳入的队列研究报告了低偏倚风险，但 RCT 显示出不确定的偏倚风险。
研究表明步态变异性可能预测发生 MCI。此外，MCI 患者可能存在多种步态参数受损，尤其是在 DT 条件下。这些参数可以通过一些身体活动干预来改善。尽管队列研究报告了低偏倚风险，但 RCT 显示出不确定的偏倚风险，GRADE 标准显示每个结局的证据水平较低，因此需要进一步研究来反驳我们的发现。
CRD42019119180。
