Center for Cohort Studies, Total Healthcare Center, School of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, Korea.
Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
J Am Coll Nutr. 2021 Aug;40(6):496-501. doi: 10.1080/07315724.2020.1800534. Epub 2020 Aug 11.
High consumption of sugar-sweetened carbonated beverage (SSCB) has been associated with multiple metabolic risk factors for cardiovascular disease. However, published data is scarce regarding the influence of SSCB consumption on left ventricular (LV) structure and diastolic function. The present study is to investigate the association of SSCB consumption with alteration in LV structure and diastolic function.
Study subjects were 46,417 Koreans who received echocardiography as an item of health checkup. They were categorized into 4 groups by SSCB consumption based on one serving dose (200 ml) with never/almost never, <1 serving/week, 1 ≤ serving/week <3 and ≥3 serving/week. Multivariate logistic regression analysis was used in calculating adjusted odd ratio (OR) and 95% confidence interval (CI) (adjusted OR [95% CI]) for left ventricular hypertrophy, increased relative wall thickness (IRWT) and impaired LV relaxation with each group (reference: never/almost never consumption). Subgroup analysis was conducted by age of ≥40 and <40.
Compared with never/almost never consumption, SSCB consumption ≥3 serving/week had the higher mean levels in body mass index, blood pressure and triglyceride despite of younger age. In fully adjusted analysis, SSCB consumption ≥3 serving/week was associated with IRWT (1.14 [1.02-1.27]) and impaired LV relaxation (1.23 [1.08-1.41]). This association was reinforced in age subgroup ≥40 years, but not statistically significant in age subgroup <40 years.
SSCB consumption ≥3 serving/week was associated with the increased probability of IRWT and impaired LV relaxation.
高糖碳酸饮料（SSCB）的大量摄入与心血管疾病多种代谢危险因素有关。然而，关于 SSCB 摄入对左心室（LV）结构和舒张功能的影响，发表的数据很少。本研究旨在探讨 SSCB 摄入与 LV 结构和舒张功能改变的关系。
研究对象为接受超声心动图作为健康检查项目的 46417 名韩国人。根据 200ml 一份的剂量，他们被分为 4 组，即从不/几乎不摄入、<1 份/周、1 份/周<3 份和≥3 份/周。多变量 logistic 回归分析用于计算调整后的比值比（OR）和 95%置信区间（CI）（调整后的 OR [95%CI]），用于评估左心室肥厚、相对壁厚度增加（IRWT）和 LV 松弛功能受损与各组（参考：从不/几乎不摄入）的关系。进行了年龄≥40 岁和<40 岁的亚组分析。
与从不/几乎不摄入相比，即使年龄较小，SSCB 摄入≥3 份/周的患者的 BMI、血压和甘油三酯水平均值更高。在完全调整分析中，SSCB 摄入≥3 份/周与 IRWT（1.14[1.02-1.27]）和 LV 松弛功能受损（1.23[1.08-1.41]）相关。这种相关性在年龄≥40 岁的亚组中得到加强，但在年龄<40 岁的亚组中没有统计学意义。
SSCB 摄入≥3 份/周与 IRWT 增加和 LV 松弛功能受损的可能性增加有关。
