Universidade de Araraquara (Uniara), Faculdade de Medicina, Divisão de Otorrinolaringologia, Araraquara, SP, Brazil.
Universidade Estadual de São Paulo (UNESP), Faculdade de Odontologia de Araraquara, Departamento de Diagnóstico e Cirurgia, Araraquara, SP, Brazil.
Braz J Otorhinolaryngol. 2022 May-Jun;88(3):296-302. doi: 10.1016/j.bjorl.2020.06.002. Epub 2020 Jul 21.
Obstructive sleep apnea is a consequence of upper airway collapse. Any obstructive sector in the upper airway can contribute to pharyngeal collapse. Obesity and obesity-related disorders play an important role in obstructive sleep apnea and its relationship with increased upper airway resistance.
This study was designed to evaluate the relationship between obesity and properties of the nasal cavity in patients with obstructive sleep apnea.
The study was conducted retrospectively by review of medical records of adult patients. The nasal obstruction symptom evaluation, NOSE instrument, was used to measure nasal obstruction. Sleep breathing disorders were evaluated by polysomnography exams. Nasal volume was obtained by computed tomography scans and volumetric reconstruction of nasal airway. Nasal anatomic alterations were assessed by nasal endoscopy.
Analysis of 83 patient records, among whom 54 were male and 29 females, found the mean body mass index of 28.69 kg/m. Obese and non-obese groups were determined by using cut-off 30 kg/m. In the comparison between groups, the obese group had a positive and significant correlation with apnea/hypopnea index (p = 0.02), NOSE instrument (p = 0.033) and inferior turbinate hypertrophy (p = 0.036), with odds ratio 1.983 (95% IC 1.048 - 3.753). nasal septum deviation (p = 0.126) and nasal airway volume evaluation (p = 0.177) showed no significant results.
Obesity was significantly correlated with subjective nasal obstruction, NOSE scale, and inferior turbinate hypertrophy in patients with obstructive sleep apnea. There was no correlation with the nasal volume evaluation.
3b - Individual case-control study.
阻塞性睡眠呼吸暂停是上气道塌陷的结果。上气道的任何阻塞部位都可能导致咽腔塌陷。肥胖和与肥胖相关的疾病在阻塞性睡眠呼吸暂停及其与上气道阻力增加的关系中起着重要作用。
本研究旨在评估肥胖与阻塞性睡眠呼吸暂停患者鼻腔特征的关系。
本研究通过回顾性分析成年患者的病历进行。使用鼻腔阻塞症状评估量表（NOSE 量表）来测量鼻腔阻塞。通过多导睡眠图检查评估睡眠呼吸障碍。通过计算机断层扫描和鼻腔气道容积重建获得鼻腔容积。通过鼻内窥镜评估鼻腔解剖结构的改变。
分析了 83 例患者的记录，其中 54 例为男性，29 例为女性，平均体重指数为 28.69kg/m。使用 30kg/m 的截止值来确定肥胖组和非肥胖组。在组间比较中，肥胖组与呼吸暂停/低通气指数（p=0.02）、NOSE 量表（p=0.033）和下鼻甲肥大（p=0.036）呈正相关，优势比为 1.983（95%置信区间 1.048-3.753）。鼻中隔偏曲（p=0.126）和鼻腔气道容积评估（p=0.177）无显著结果。
肥胖与阻塞性睡眠呼吸暂停患者的主观鼻腔阻塞、NOSE 量表和下鼻甲肥大显著相关，与鼻腔容积评估无相关性。
3b - 个体病例对照研究。
