Institute of Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.
J Mater Chem B. 2020 Aug 26;8(33):7319-7334. doi: 10.1039/d0tb01245a.
With recent developments in the field of autonomous motion for artificial systems, many researchers are focusing on their biomedical application for active and targeted delivery. In this context, enzyme powered motors are at the forefront since they can utilize physiologically relevant fuels as their substrate and carry out catalytic reactions to power motion under in vivo conditions. This review focuses on the design and fabrication of enzyme powered motors together with their propulsion mechanism by using fuels present in biological environments. In addition, the recent advances in the field of enzyme powered motors for biomedical applications have been discussed together with the parameters that need to be considered for designing such systems. We believe that this review will provide insights and better understanding for the development of next generation biomedical technologies based on enzyme powered motors.
随着人工系统自主运动领域的最新发展，许多研究人员正专注于将其生物医学应用于主动和靶向输送。在这种情况下，酶动力马达处于前沿地位，因为它们可以利用生理相关的燃料作为底物，并在体内条件下进行催化反应来驱动运动。本综述重点介绍了酶动力马达的设计和制造及其推进机制，使用了生物环境中存在的燃料。此外，还讨论了酶动力马达在生物医学应用方面的最新进展，以及设计此类系统时需要考虑的参数。我们相信，这篇综述将为基于酶动力马达的下一代生物医学技术的发展提供见解和更好的理解。
