Lei Shan, Zhang Yifan, Blum Nicholas Thomas, Huang Peng, Lin Jing
Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China.
Bioconjug Chem. 2020 Sep 16;31(9):2072-2084. doi: 10.1021/acs.bioconjchem.0c00356. Epub 2020 Aug 17.
Croconaine (CR) dyes, the donor-acceptor-donor (D-A-D) type zwitterionic compounds with extended π-conjugation, can be readily synthesized via a straightforward condensation reaction. They have received much attention in bioimaging and theranostics, owing to their tailored structures and fascinating near-infrared (NIR) photophysical properties. In this topical review, we summarize the recent advances in biomedical applications for CR dyes. First, we introduce the classification and optical performance of CR dyes. Next, we highlight the chemistry and applications of CR dyes in bioimaging and theranostics. Finally, the summary and prospects of CR dyes for bioimaging and theranostics are discussed.
克罗卡宁（CR）染料是具有扩展π共轭的供体-受体-供体（D-A-D）型两性离子化合物，可通过简单的缩合反应轻松合成。由于其定制的结构和迷人的近红外（NIR）光物理性质，它们在生物成像和治疗诊断学中受到了广泛关注。在这篇专题综述中，我们总结了CR染料在生物医学应用方面的最新进展。首先，我们介绍了CR染料的分类和光学性能。接下来，我们重点介绍了CR染料在生物成像和治疗诊断学中的化学性质及应用。最后，讨论了CR染料在生物成像和治疗诊断学方面的总结与展望。
