牛分枝杆菌感染后家兔对梅毒螺旋体的易感性。
Susceptibility of rabbits to Treponema pallidum after infection with Mycobacterium bovis.
作者信息
Graves S
出版信息
Br J Vener Dis. 1979 Dec;55(6):394-8. doi: 10.1136/sti.55.6.394.
Abstract
Rabbits stimulated with Mycobacterium bovis (strain BCG) one month before challenge with Treponema pallidum (Nichols) did not show any modification in their development of syphilitic lesions. A second infection with BCG given at the same time and at the same intradermal site as the T. pallidum challenge also failed to protect the rabbits against syphilis. Thus the non-specific activation of cell-mediated immunity by BCG does not appear to protect rabbits against T. pallidum infection even when both activation and challenge take place in the dermis. The role of the macrophage in syphilis remains obscure.
摘要
在感染梅毒螺旋体（Nichols株）前一个月用牛分枝杆菌（卡介苗菌株）刺激的兔子，其梅毒病变的发展没有任何改变。在与梅毒螺旋体攻击相同的时间和相同的皮内部位再次接种卡介苗，也未能保护兔子免受梅毒感染。因此，即使激活和攻击都发生在真皮层，卡介苗对细胞介导免疫的非特异性激活似乎也不能保护兔子免受梅毒螺旋体感染。巨噬细胞在梅毒中的作用仍不清楚。
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