牛分枝杆菌感染后家兔对梅毒螺旋体的易感性。
Susceptibility of rabbits to Treponema pallidum after infection with Mycobacterium bovis.
作者信息
Graves S
出版信息
Br J Vener Dis. 1979 Dec;55(6):394-8. doi: 10.1136/sti.55.6.394.
Abstract
Rabbits stimulated with Mycobacterium bovis (strain BCG) one month before challenge with Treponema pallidum (Nichols) did not show any modification in their development of syphilitic lesions. A second infection with BCG given at the same time and at the same intradermal site as the T. pallidum challenge also failed to protect the rabbits against syphilis. Thus the non-specific activation of cell-mediated immunity by BCG does not appear to protect rabbits against T. pallidum infection even when both activation and challenge take place in the dermis. The role of the macrophage in syphilis remains obscure.
摘要
在感染梅毒螺旋体（Nichols株）前一个月用牛分枝杆菌（卡介苗菌株）刺激的兔子，其梅毒病变的发展没有任何改变。在与梅毒螺旋体攻击相同的时间和相同的皮内部位再次接种卡介苗，也未能保护兔子免受梅毒感染。因此，即使激活和攻击都发生在真皮层，卡介苗对细胞介导免疫的非特异性激活似乎也不能保护兔子免受梅毒螺旋体感染。巨噬细胞在梅毒中的作用仍不清楚。
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本文引用的文献
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The effect of the method of inoculation upon the course of experimental syphilis in the rabbit.接种方法对家兔实验性梅毒病程的影响。
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A study on the Wassermann and TPI antibodies in relation to histopathological findings in T. pallidum infected animals and man.一项关于梅毒螺旋体感染动物及人类中瓦色曼氏反应和螺旋体制动抗体与组织病理学发现关系的研究。
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Cell-mediated immunity and lymphocyte transformation in syphilis.梅毒中的细胞介导免疫与淋巴细胞转化
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An electron microscopic study of a syphilitic chancre. Engulfment of Treponema pallidum by plasma cells.梅毒初疮的电子显微镜研究。浆细胞对梅毒螺旋体的吞噬作用。
Arch Pathol. 1970 Aug;90(2):143-50.
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Effects of passive immunization on experimental syphilis in the rabbit.被动免疫对兔实验性梅毒的影响。
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Immunity to syphilis. I. Passive transfer in rabbits with hyperimmune serum.梅毒免疫。一、用超免疫血清在兔体内进行被动转移
Infect Immun. 1973 Nov;8(5):787-90. doi: 10.1128/iai.8.5.787-790.1973.
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Attempt to protect rabbits against experimental syphilis by passive immunization.尝试通过被动免疫保护兔子免受实验性梅毒感染。
Br J Vener Dis. 1973 Aug;49(4):335-7. doi: 10.1136/sti.49.4.335.
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Serial ultrathin sectioning demonstrating the intracellularity of T. Pallidum. An electron microscopic study.连续超薄切片显示梅毒螺旋体的细胞内存在情况。一项电子显微镜研究。
Br J Vener Dis. 1972 Apr;48(2):87-96. doi: 10.1136/sti.48.2.87.
10
Cell response in rabbits infected with T. pallidum as measured by the leucocyte migration inhibition test.通过白细胞游走抑制试验测定感染梅毒螺旋体的家兔的细胞反应。
Br J Vener Dis. 1975 Aug;51(4):240-5. doi: 10.1136/sti.51.4.240.
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