College of Materials Science and Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Rd., Qingdao, Shandong, 266042, China.
Department of Chemistry, University of Houston, 4800 Calhoun Road, Houston, Texas, 77204, USA.
Colloids Surf B Biointerfaces. 2020 Dec;196:111313. doi: 10.1016/j.colsurfb.2020.111313. Epub 2020 Aug 9.
Gold nanoclusters decorated amine-functionalized graphene oxide (Au-GO-NH) nanosheets were designed as a highly efficient visible light active antibacterial agent. This assembled nanosheet is positively charged and of high specific surface area that captures bacteria through physical adsorption and electrostatic interaction. Under visible light irradiation, this photoactive nanosheet concurrently generates massive heat and produces substantial reactive oxygen species to inactivate bacteria. In comparison with bare gold nanoclusters and amine-functionalized graphene oxides, this nanosheet appears an enhanced antibacterial activity >5-fold towards Gram-postive and Gram-negative bacteria. Moreover, a nanosheet modified silicone surface was employed as a model of implant devices, which showed superior antibacterial efficacy against bacterial colonization in vitro. This work demonstrates that the assembled nanosheet is a promising novel strategy in the construction of next generation antimicrobial agent for synergistic bacterial capture, oxidative stress, and photothermal ablation in the biomedical and environmental fields.
金纳米簇修饰的胺功能化氧化石墨烯（Au-GO-NH）纳米片被设计为一种高效的可见光活性抗菌剂。这种组装的纳米片带正电荷，具有高比表面积，可以通过物理吸附和静电相互作用捕获细菌。在可见光照射下，这种光活性纳米片同时产生大量热量并产生大量活性氧物质来灭活细菌。与裸露的金纳米簇和胺功能化氧化石墨烯相比，这种纳米片对革兰氏阳性菌和革兰氏阴性菌的抗菌活性提高了 5 倍以上。此外，还将纳米片修饰的硅酮表面用作植入装置的模型，该模型在体外表现出对细菌定植的优异抗菌效果。这项工作表明，组装的纳米片是一种很有前途的新型策略，可用于构建下一代抗菌剂，以协同捕获细菌、氧化应激和光热消融，应用于生物医学和环境领域。
