Zhang Xinrong, Goh George B-B, Chan Wah-Kheong, Wong Grace L-H, Fan Jian-Gao, Seto Wai-Kay, Huang Yi-Hsiang, Lin Han-Chieh, Lee I-Cheng, Lee Hye Won, Kim Seung Up, Chow Wan Cheng, Wong Vincent W-S
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
Liver Int. 2020 Nov;40(11):2719-2731. doi: 10.1111/liv.14638. Epub 2020 Oct 13.
BACKGROUND & AIMS: Lifestyle modification is the cornerstone for the management of non-alcoholic fatty liver disease (NAFLD). We aim to understand lifestyle habits of NAFLD patients, compare across Asian regions and identify area of deficiency.
In the multi-centre controlled attenuation parameter (CAP)-Asia study, we collected clinical data and lifestyle habit data of NAFLD patients from Singapore, mainland China, Hong Kong, Taiwan and Malaysia. Physical activity was assessed using the International Physical Activity Questionnaire.
A total of 555 patients were included in the final analysis (mean age 54.5 ± 11.2 years, 54.1% men and median liver stiffness 6.7 kPa). More patients from mainland China (27.4%) and Taipei (25.0%) were smokers. Modest drinking was more common in Taiwan (25.0%) and Hong Kong (18.2%); only 1.3% had binge drinking. Majority of patients drank coffee (64.0%) and tea (80.2%), with varying amounts and durations in different regions. Soft drinks consumption was most common in Singapore (62.2%) and Malaysia (57.7%). Only 29.7% of patients met the Physical Activity Guidelines Recommendations, with no major differences across regions. Patients with liver stiffness <10 kPa were more likely to report any vigorous activity, and sitting time was an independent factor associated with high CAP. Tea and coffee consumption were independently associated with high CAP and liver stiffness, respectively.
Despite some heterogeneity, unhealthy lifestyle and physical inactivity are common across Asian regions. Patients with liver stiffness <10 kPa were more likely to report any vigorous activity. Healthcare providers may use the comparative data to identify areas of deficiency.
生活方式改变是非酒精性脂肪性肝病（NAFLD）管理的基石。我们旨在了解NAFLD患者的生活习惯，比较亚洲不同地区的情况，并确定不足之处。
在多中心控制衰减参数（CAP）-亚洲研究中，我们收集了来自新加坡、中国大陆、香港、台湾和马来西亚的NAFLD患者的临床数据和生活习惯数据。使用国际体力活动问卷评估体力活动情况。
共有555例患者纳入最终分析（平均年龄54.5±11.2岁，男性占54.1%，肝硬度中位数为6.7 kPa）。中国大陆（27.4%）和台北（25.0%）的吸烟者较多。适度饮酒在台湾（25.0%）和香港（18.2%）更为常见；只有1.3%的人有暴饮行为。大多数患者喝咖啡（64.0%）和茶（80.2%），不同地区的饮用量和饮用时间各不相同。软饮料消费在新加坡（62.2%）和马来西亚（57.7%）最为普遍。只有29.7%的患者达到体力活动指南建议，各地区之间无显著差异。肝硬度<10 kPa的患者更有可能报告进行任何剧烈活动，久坐时间是与高CAP相关的独立因素。茶和咖啡消费分别与高CAP和肝硬度独立相关。
尽管存在一些异质性，但不健康的生活方式和缺乏体育活动在亚洲各地区都很常见。肝硬度<10 kPa的患者更有可能报告进行任何剧烈活动。医疗保健提供者可以利用这些比较数据来确定不足之处。
