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非酒精性脂肪性肝病诊断与监测的非侵入性技术全球趋势：文献计量与可视化分析

Global Trends in Non-Invasive Techniques for the Diagnosis and Monitoring of Nonalcoholic Fatty Liver Disease: A Bibliometric and Visualization Analysis.

作者信息

Cai Jing-Wen, Wang Wei-Long, Lin Dong-Ling, Ren Shu-Feng, Jia Qian-Qian, He Xiao-Xuan, Yang Xue-Xia, Cai Wen, Hou Hui

机构信息

Department of Nursing, Xinjiang Medical University, Urumqi, People's Republic of China.

Department of Infectious Diseases, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China.

出版信息

J Multidiscip Healthc. 2025 Jul 26;18:4243-4266. doi: 10.2147/JMDH.S525751. eCollection 2025.

DOI:10.2147/JMDH.S525751
PMID:40741077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12309579/
Abstract

BACKGROUND

Nonalcoholic fatty liver disease (NAFLD) is a globally prevalent condition. Emerging technologies like biomarkers, imaging, multi-omics, and artificial intelligence (AI) are driving research into non-invasive diagnosis and monitoring.

OBJECTIVE

To provide a comprehensive overview of the hotspots and future research trends in non-invasive diagnosis and monitoring of NAFLD.

METHODS

A search of the Web of Science Core Collection database identified 1136 articles that met the study criteria between April 1, 2005, and December 31, 2024. By integrating various bibliometric methods and tools, we conducted a comprehensive analysis.

RESULTS

Publication growth reflects robust research interest. The United States and China are the leading countries, and the University of California, San Diego tops the institutions. Liver International and PLOS ONE publish the most relevant articles, while Journal of Hepatology is the most influential. "Transient elastography", "fibrosis" and "diagnosis" are prominent keywords. Research trends are shifting from basic to clinical applications, with a focus on non-invasive techniques, biomarkers and disease models.

CONCLUSION

Future investigations will focus on the clinical application of these techniques. Global collaboration is expected to enhance NAFLD diagnosis, treatment, prevention, and monitoring.

摘要

背景

非酒精性脂肪性肝病（NAFLD）是一种全球普遍存在的疾病。生物标志物、成像、多组学和人工智能（AI）等新兴技术正在推动非侵入性诊断和监测的研究。

目的

全面概述NAFLD非侵入性诊断和监测的热点及未来研究趋势。

方法

检索科学网核心合集数据库，确定了2005年4月1日至2024年12月31日期间符合研究标准的1136篇文章。通过整合各种文献计量方法和工具，我们进行了全面分析。

结果

发表量的增长反映出浓厚的研究兴趣。美国和中国是领先国家，加利福尼亚大学圣地亚哥分校位居机构之首。《肝脏国际》和《公共科学图书馆·综合》发表的相关文章最多，而《肝脏病学杂志》最具影响力。“瞬时弹性成像”“纤维化”和“诊断”是突出的关键词。研究趋势正从基础研究转向临床应用，重点是非侵入性技术、生物标志物和疾病模型。

结论

未来的研究将聚焦于这些技术的临床应用。预计全球合作将加强NAFLD的诊断、治疗、预防和监测。

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