Indonesian-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.
Center for Infectious Diseases, Kobe University Graduate School of Medicine, Hyogo, Japan.
AIDS Res Hum Retroviruses. 2020 Nov;36(11):957-963. doi: 10.1089/AID.2020.0151. Epub 2020 Sep 28.
The HIV type 1 (HIV-1) epidemic has continued to grow in Indonesia; however, continuous updates on the epidemiology of HIV-1 in Indonesia remain challenging because it is the biggest archipelago in the world. Furthermore, the emergence of HIV drug resistance (HIVDR) has had a negative impact on the treatment of infected individuals. In this study, we performed HIV-1 subtyping and the detection of HIVDR in 105 HIV-1-infected individuals residing in various cities in Indonesia during 2018-2019. The results obtained identified CRF01_AE as the major epidemic HIV-1 strain, responsible for 81.9% of infection cases, followed by subtype B (12.4%), CRF02_AG (3.8%), CRF52_01B (1%), and a recombinant between CRF01_AE and CRF02_AG (1.0%). Major drug resistance-associated mutations against reverse transcriptase inhibitors were detected in 20% of samples. These results suggest that CRF01_AE is a major HIV-1 strain in Indonesia, while CRF02_AG is emerging. The prevalence of HIVDR in Indonesia needs to be monitored.
艾滋病毒 1 型（HIV-1）在印度尼西亚继续蔓延；然而，由于印度尼西亚是世界上最大的群岛国家，持续更新其 HIV-1 流行病学信息仍然具有挑战性。此外，HIV 耐药性（HIVDR）的出现对受感染者的治疗产生了负面影响。在这项研究中，我们对 2018 年至 2019 年期间居住在印度尼西亚不同城市的 105 名 HIV-1 感染者进行了 HIV-1 亚型分析和 HIVDR 检测。结果表明，CRF01_AE 是主要流行的 HIV-1 株，占感染病例的 81.9%，其次是 B 亚型（12.4%）、CRF02_AG（3.8%）、CRF52_01B（1%）和 CRF01_AE 与 CRF02_AG 之间的重组型（1.0%）。在 20%的样本中检测到针对逆转录酶抑制剂的主要耐药相关突变。这些结果表明，CRF01_AE 是印度尼西亚的主要 HIV-1 株，而 CRF02_AG 正在出现。需要监测印度尼西亚的 HIVDR 流行情况。
