星形胶质细胞在中枢神经系统炎症中的作用。
The Role of Astrocytes in CNS Inflammation.
机构信息
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
出版信息
Trends Immunol. 2020 Sep;41(9):805-819. doi: 10.1016/j.it.2020.07.007. Epub 2020 Aug 13.
Abstract
Astrocytes are the most abundant cell type in the central nervous system (CNS), performing complex functions in health and disease. It is now clear that multiple astrocyte subsets or activation states (plastic phenotypes driven by intrinsic and extrinsic cues) can be identified, associated to specific genomic programs and functions. The characterization of these subsets and the mechanisms that control them may provide unique insights into the pathogenesis of neurologic diseases, and identify potential targets for therapeutic intervention. In this article, we provide an overview of the role of astrocytes in CNS inflammation, highlighting recent discoveries on astrocyte subsets and the mechanisms that control them.
摘要
星形胶质细胞是中枢神经系统（CNS）中最丰富的细胞类型，在健康和疾病中发挥着复杂的功能。现在已经很清楚，可以识别出多种星形胶质细胞亚群或激活状态（由内在和外在线索驱动的可塑性表型），与特定的基因组程序和功能相关。这些亚群的特征及其控制机制可能为神经疾病的发病机制提供独特的见解，并确定潜在的治疗干预靶点。在本文中，我们概述了星形胶质细胞在 CNS 炎症中的作用，强调了最近关于星形胶质细胞亚群及其控制机制的发现。
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