Muslimin Lukman, Burhan Asril, Khairuddin Khairuddin, Kriswanty Cicilia, Arsyandi Aswal, Megawati Megawati
Department of Pharmaceutical Chemistry, Sekolah Tinggi Ilmu Farmasi Makassar, Perintis Kemerdekaan, Makassar, Indonesia.
Department of Biological Pharmacy, Sekolah Tinggi Ilmu Farmasi Makassar, Perintis Kemerdekaan, Makassar, Indonesia.
J Pharm Bioallied Sci. 2020 Jan-Mar;12(1):77-81. doi: 10.4103/jpbs.JPBS_148_19. Epub 2020 Jan 29.
This study sought to investigate the chemical composition, larvicidal, and cytotoxic potentials of the fruit extract of Reinw.
The chemical composition was analyzed using the gas chromatography-mass spectrometry technique. Separately, mortality data were evaluated by probit analysis to determine the lethal concentration (LC) and LC values on brine shrimp and larvae. Moreover, the effects on different stages of were also examined.
Fourteen majority components representing carboxylic acid were identified. The extract was very toxic to both brine shrimp and larvae with LC values of 0.308 and 0.514 µg/mL, whereas the LC values were 4.317 and 1.921 µg/mL, respectively. The effect of the fruit extract of on different stages of indicated that high concentrations (2.00-4.00 µg/mL) promoted complete mortality. A concentration of 0.125 to 1.00 µg/mL inhibited larval metamorphosis.
To the best of our knowledge, this is the first study to evaluate the chemical composition and larvicidal effects of the fruit extract of . The results indicate that the extract may be a promising source of larvicidal compounds that could be useful for pharmaceutical applications.
本研究旨在调查 Reinw.果实提取物的化学成分、杀幼虫潜力和细胞毒性。
采用气相色谱 - 质谱技术分析化学成分。另外，通过概率分析评估死亡率数据，以确定对卤虫和幼虫的致死浓度（LC）及LC值。此外，还研究了其对[某种生物]不同阶段的影响。
鉴定出了14种主要的羧酸类成分。该提取物对卤虫和幼虫均具有很高毒性，卤虫的LC值为0.308 μg/mL，幼虫的LC值为0.514 μg/mL，而[另一种生物]的LC值分别为4.317 μg/mL和1.921 μg/mL。Reinw.果实提取物对[某种生物]不同阶段的影响表明，高浓度（2.00 - 4.00 μg/mL）可导致完全死亡。浓度为0.125至1.00 μg/mL时可抑制幼虫变态。
据我们所知，这是首次评估Reinw.果实提取物化学成分和杀幼虫作用的研究。结果表明，该提取物可能是一种有前景的杀幼虫化合物来源，可用于制药应用。
