Steno Diabetes Center Copenhagen, Niels Steensens Vej 2-4, DK-2820, Gentofte, Denmark.
Curr Diab Rep. 2020 Aug 15;20(9):46. doi: 10.1007/s11892-020-01326-8.
The underlying factors triggering a cascade of autoimmune response that leads to the death of pancreatic beta cells and type 1 diabetes are to large extent unknown. Aberrations in the lipid balance have been suggested, either as factors directly contributing to autoimmunity or as a reflection of external factors, such as the diet or chemical exposure, which may increase the risk or even trigger the autoimmunity cascade.
A small number of recent studies have investigated the blood lipidome before and after the onset of type 1 diabetes with a goal of identifying biomarkers of disease progression. Phosphatidylcholine levels in particular have been suggested to be reduced prior to the onset of type 1 diabetes. In this review, we approach this question through a quantitative analysis of the reported lipids. We quantify the extent of consensus between these heterogeneous studies, describe the overall lipidomic pattern that has been reported, and call for more independent replication of the findings that we highlight in this review.
综述目的：导致胰岛β细胞死亡和 1 型糖尿病的自身免疫反应级联的潜在因素在很大程度上尚不清楚。有人提出脂质平衡异常，无论是作为直接导致自身免疫的因素，还是作为饮食或化学暴露等外部因素的反映，这些因素可能会增加自身免疫级联反应的风险甚至引发其发生。
最新发现：少数近期研究调查了 1 型糖尿病发病前后的血液脂质组学，旨在确定疾病进展的生物标志物。有人提出，在 1 型糖尿病发病前，磷酸胆碱水平降低。在本综述中，我们通过对报道的脂质进行定量分析来探讨这个问题。我们量化了这些异质研究之间的一致性程度，描述了已报道的总体脂质组学模式，并呼吁对我们在本综述中强调的发现进行更多的独立复制。
