Universidade da Coruña, Grupo DICOMOSA, Centro de Investigaciones Científicas Avanzadas (CICA), Departamento de Psicología, Facultad de Ciencias de la Educación, Campus Elviña s/n, 15071, A Coruña, Spain.
Instituto de Investigación Biomédica de A Coruña (INIBIC), AE CICA-INIBIC, Oza, 15071, A Coruña, Spain.
Geroscience. 2020 Dec;42(6):1451-1473. doi: 10.1007/s11357-020-00247-4. Epub 2020 Aug 15.
Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. "Inflammaging", an age-related state of low-grade chronic inflammation, is characterized by an increased concentration of pro-inflammatory cytokines and acute phase proteins. Inflammaging has been postulated as an underlying mechanism of frailty, and several studies tested the relationship between frailty and concentration of inflammatory mediators. The aim of this systematic review and meta-analysis was to test whether inflammatory mediators are overproduced in frail older adults. Among the 758 articles identified in the literature search, 50 were included in the systematic review, and 39 in the three meta-analyses, i.e., C-reactive protein (CRP), interleukin 6 (IL6), and tumor necrosis factor α. To reduce heterogeneity, meta-analyses were restricted to studies identifying frailty by the Fried et al. [1] [J. Gerontol. A. Biol. Sci. Med. Sci. 56, M146-56] phenotypic criteria. Quantitative analyses measuring the association between frailty and biomarker concentrations showed significant differences when frail subjects were compared to non-frail and pre-frail subjects for CRP and IL6. This work established strong association between inflammatory biomarkers and frailty, confirming the role of age-related chronic inflammation in frailty development.
衰弱是一种老年综合征，定义为对压力源极度脆弱的状态，导致负面健康相关结果的风险更高。“炎老化”是一种与年龄相关的低度慢性炎症状态，其特征是促炎细胞因子和急性期蛋白浓度增加。炎老化被认为是衰弱的潜在机制，有几项研究测试了衰弱与炎症介质浓度之间的关系。本系统评价和荟萃分析的目的是测试炎症介质是否在虚弱的老年人中过度产生。在文献检索中确定的 758 篇文章中，有 50 篇被纳入系统评价，有 39 篇被纳入三个荟萃分析，即 C 反应蛋白（CRP）、白细胞介素 6（IL6）和肿瘤坏死因子 α。为了降低异质性，荟萃分析仅限于通过 Fried 等人[1] [J. Gerontol. A. Biol. Sci. Med. Sci. 56, M146-56]表型标准确定衰弱的研究。定量分析测量衰弱与生物标志物浓度之间的关联表明，与非虚弱和虚弱前受试者相比，CRP 和 IL6 时虚弱受试者存在显著差异。这项工作确立了炎症生物标志物与衰弱之间的强烈关联，证实了与年龄相关的慢性炎症在衰弱发展中的作用。
