Muchová Monika, Münster Lukáš, Capáková Zdenka, Mikulcová Veronika, Kuřitka Ivo, Vícha Jan
Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, 760 01 Zlín, Czech Republic.
Centre of Polymer Systems, Tomas Bata University in Zlín, tř. Tomáše Bati 5678, 760 01 Zlín, Czech Republic.
Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111242. doi: 10.1016/j.msec.2020.111242. Epub 2020 Jun 26.
2,3-Dialdehyde cellulose (DAC) was used as an efficient and low-toxicity crosslinker to prepare thin PVA/DAC hydrogel films designed for topical applications such as drug-loaded patches, wound dressings or cosmetic products. An optimization of hydrogel properties was achieved by the variation of two factors - the amount of crosslinker and the weight-average molecular weight (M) of the source PVA. The role of each factor to network parameters, mechanical, rheological and surface properties, hydrogel porosity and transdermal absorption is discussed. The best results were obtained for hydrogel films prepared using 0.25 wt% of DAC and PVA with M = 130 kDa, which had a high porosity and drug-loading capacity (high water content), mechanical properties allowing easy handling, best adherence to the skin from all tested samples and improved transdermal drug-delivery. Hydrogel films are biocompatible, show no cytotoxicity and have no negative impact on cell growth and morphology in their presence. Furthermore, hydrogels do not support cell migration and attachment to their surface, which should ensure easy removal of hydrogel patches even from wounded or damaged skin after use.
2,3-二醛基纤维素（DAC）被用作一种高效且低毒的交联剂，以制备用于局部应用的薄型聚乙烯醇/ DAC水凝胶薄膜，如载药贴片、伤口敷料或化妆品。通过改变两个因素——交联剂的用量和源聚乙烯醇的重均分子量（M），实现了水凝胶性能的优化。讨论了每个因素对网络参数、机械、流变和表面性能、水凝胶孔隙率和透皮吸收的作用。对于使用0.25 wt% DAC和M = 130 kDa的聚乙烯醇制备的水凝胶薄膜，获得了最佳结果，该薄膜具有高孔隙率和载药能力（高含水量），机械性能便于操作，在所有测试样品中对皮肤的粘附性最佳，并且改善了透皮给药。水凝胶薄膜具有生物相容性，无细胞毒性，在其存在下对细胞生长和形态没有负面影响。此外，水凝胶不支持细胞迁移和附着在其表面，这应确保即使在使用后，也能轻松从受伤或受损皮肤上去除水凝胶贴片。
