Miulescu Raluca, Balaban Daniel Vasile, Sandru Florica, Jinga Mariana
Dermatology Department, Elias University Emergency Hospital, 011461 Bucharest, Romania.
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 030167 Bucharest, Romania.
J Clin Med. 2020 Aug 12;9(8):2611. doi: 10.3390/jcm9082611.
Pancreatic pathology, comprising acute and chronic pancreatitis, autoimmune pancreatitis and pancreatic neoplasms, primarily presents with gastrointestinal symptoms and signs; however, it is well recognized that it can also associate a wide range of extra-digestive features. Among these systemic manifestations, cutaneous involvement plays an important role both as a diagnostic clue for the pancreatic disease itself and serving as a prognostic factor for the severity of the condition. Recognition of these cutaneous signs is, however, far from being satisfactory, all the more as some of them are relatively rare. In the current review, we discuss skin involvement in pancreatic diseases, referring to pancreatic panniculitis, cutaneous hemorrhagic manifestations, skin metastasis, acanthosis nigricans, livedo reticularis, necrolytic migratory erythema and cutaneous fistula. We highlight the clinical characteristics, treatment and prognostic value of these lesions. Better awareness among medical specialties other than dermatology is needed for detection of the skin clues associated with pancreatic pathology.
胰腺病理学包括急性和慢性胰腺炎、自身免疫性胰腺炎以及胰腺肿瘤，主要表现为胃肠道症状和体征；然而，人们已经充分认识到它也可能伴有多种消化系统外的特征。在这些全身表现中，皮肤受累无论是作为胰腺疾病本身的诊断线索，还是作为病情严重程度的预后因素，都起着重要作用。然而，对这些皮肤体征的认识远不能令人满意，尤其是其中一些相对罕见。在本综述中，我们讨论胰腺疾病中的皮肤受累情况，涉及胰腺性脂膜炎、皮肤出血表现、皮肤转移、黑棘皮病、网状青斑、坏死性游走性红斑和皮肤瘘管。我们强调这些病变的临床特征、治疗方法和预后价值。除皮肤科外，其他医学专科需要提高对与胰腺病理学相关的皮肤线索的认识，以便进行检测。
