Cristallini Caterina, Vitale Emanuela, Giachino Claudia, Rastaldo Raffaella
Institute for Chemical and Physical Processes, IPCF ss Pisa, Italian National Research Council (CNR), 56126 Pisa, Italy.
Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Torino, Italy.
Nanomaterials (Basel). 2020 Aug 12;10(8):1587. doi: 10.3390/nano10081587.
To deliver on the promise of cardiac regeneration, an integration process between an emerging field, nanomedicine, and a more consolidated one, tissue engineering, has begun. Our work aims at summarizing some of the most relevant prevailing cases of nanotechnological approaches applied to tissue engineering with a specific interest in cardiac regenerative medicine, as well as delineating some of the most compelling forthcoming orientations. Specifically, this review starts with a brief statement on the relevant clinical need, and then debates how nanotechnology can be combined with tissue engineering in the scope of mimicking a complex tissue like the myocardium and its natural extracellular matrix (ECM). The interaction of relevant stem, precursor, and differentiated cardiac cells with nanoengineered scaffolds is thoroughly presented. Another correspondingly relevant area of experimental study enclosing both nanotechnology and cardiac regeneration, e.g., nanoparticle applications in cardiac tissue engineering, is also discussed.
为了实现心脏再生的承诺，一个新兴领域——纳米医学，与一个更成熟的领域——组织工程之间的整合过程已经开始。我们的工作旨在总结一些将纳米技术应用于组织工程的最相关的主流案例，尤其关注心脏再生医学，并勾勒出一些最引人注目的未来发展方向。具体而言，本综述首先简要阐述相关的临床需求，然后探讨在模拟像心肌及其天然细胞外基质（ECM）这样的复杂组织的范围内，纳米技术如何与组织工程相结合。全面介绍了相关的干细胞、前体细胞和分化的心脏细胞与纳米工程支架的相互作用。还讨论了另一个同样相关的实验研究领域，该领域涵盖纳米技术和心脏再生，例如纳米颗粒在心脏组织工程中的应用。
