Roles of N -methyladenosine (m A) RNA modifications in urological cancers.

Epigenetics has long been a hot topic in the field of scientific research. The scope of epigenetics usually includes chromatin remodelling, DNA methylation, histone modifications, non-coding RNAs and RNA modifications. In recent years, RNA modifications have emerged as important regulators in a variety of physiological processes and in disease progression, especially in human cancers. Among the various RNA modifications, m A is the most common. The function of m A modifications is mainly regulated by 3 types of proteins: m A methyltransferases (writers), m A demethylases (erasers) and m A-binding proteins (readers). In this review, we focus on RNA m A modification and its relationship with urological cancers, particularly focusing on its roles and potential clinical applications.