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作为评估移植机会的指标,肾脏移植项目候补名单率。

Kidney transplant program waitlisting rate as a metric to assess transplant access.

机构信息

Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA.

Department of Surgery, Division of Transplantation, Emory University School of Medicine, Atlanta, Georgia, USA.

出版信息

Am J Transplant. 2021 Jan;21(1):314-321. doi: 10.1111/ajt.16277. Epub 2020 Sep 15.

Abstract

Kidney transplant program performance in the United States is commonly measured by posttransplant outcomes. Inclusion of pretransplant measures could provide a more comprehensive assessment of transplant program performance and necessary information for patient decision-making. In this study, we propose a new metric, the waitlisting rate, defined as the ratio of patients who are waitlisted in a center relative to the person-years referred for evaluation to a program. Furthermore, we standardize the waitlisting rate relative to the state average in Georgia, North Carolina, and South Carolina. The new metric was used as a proof-of-concept to assess transplant-program access compared to the existing transplant rate metric. The study cohorts were defined by linking 2017 United States Renal Data System (USRDS) data with transplant-program referral data from the Southeastern United States between January 1, 2012 and December 31, 2016. Waitlisting rate varied across the 9 Southeastern transplant programs, ranging from 10 to 22 events per 100 patient-years, whereas the program-specific waitlisting rate ratio ranged between 0.76 and 1.33. Program-specific waitlisting rate ratio was uncorrelated with the transplant rate ratio (r = -.15, 95% CI, -0.83 to 0.57). Findings warrant collection of national data on early transplant steps, such as referral, for a more comprehensive assessment of transplant program performance and pretransplant access.

摘要

美国的肾脏移植项目表现通常通过移植后的结果来衡量。纳入移植前的指标可以更全面地评估移植项目的表现,并为患者的决策提供必要的信息。在这项研究中,我们提出了一个新的指标,即候补率,定义为中心的候补患者人数与转诊到项目的评估人年数的比例。此外,我们将候补率相对于佐治亚州、北卡罗来纳州和南卡罗来纳州的州平均水平进行了标准化。该新指标被用作概念验证,用于评估与现有移植率指标相比的移植项目准入情况。研究队列是通过将 2017 年美国肾脏数据系统(USRDS)的数据与 2012 年 1 月 1 日至 2016 年 12 月 31 日期间美国东南部的移植项目转诊数据相链接来定义的。候补率在 9 个东南移植项目中存在差异,范围为每 100 患者-年 10 至 22 例,而特定项目的候补率比值范围在 0.76 至 1.33 之间。特定项目的候补率比值与移植率比值不相关(r = -.15,95%CI,-0.83 至 0.57)。研究结果表明,有必要收集关于早期移植步骤(如转诊)的全国数据,以更全面地评估移植项目的表现和移植前的准入情况。

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