Tymm Carly, Zhou Junhu, Tadimety Amogha, Burklund Alison, Zhang John X J
Thayer School of Engineering, Dartmouth College, Hanover, NH USA.
Cell Mol Bioeng. 2020 Aug 10;13(4):313-329. doi: 10.1007/s12195-020-00642-z. eCollection 2020 Aug.
The emergence of a novel coronavirus, SARS-CoV-2, has highlighted the need for rapid, accurate, and point-of-care diagnostic testing. As of now, there is not enough testing capacity in the world to meet the stated testing targets, which are expected to skyrocket globally for broader testing during reopening.
This review focuses on the development of lab-on-chip biosensing platforms for diagnosis of COVID-19 infection.
We discuss advantages of utilizing lab-on-chip technologies in response to the current global pandemic, including their potential for low-cost, rapid sample-to-answer processing times, and ease of integration into a range of healthcare settings. We then highlight the development of magnetic, colorimetric, plasmonic, electrical, and lateral flow-based lab-on-chip technologies for the detection of SARS-CoV-2, in addition to other viruses. We focus on rapid, point-of-care technologies that can be deployed at scale, as such devices could be promising alternatives to the current gold standard of reverse transcription-polymerase chain reaction (RT-PCR) diagnostic testing.
This review is intended to provide an overview of the current state-of-the-field and serve as a resource for innovative development of new lab-on-chip assays for COVID-19 detection.
新型冠状病毒SARS-CoV-2的出现凸显了快速、准确和即时诊断检测的必要性。截至目前，全球的检测能力不足以满足既定的检测目标，预计在重新开放期间，为进行更广泛检测，全球检测需求将急剧飙升。
本综述聚焦于用于诊断COVID-19感染的芯片实验室生物传感平台的发展。
我们讨论了在应对当前全球大流行时利用芯片实验室技术的优势，包括其实现低成本、快速样本到结果处理时间以及易于集成到一系列医疗环境中的潜力。然后，我们重点介绍了用于检测SARS-CoV-2以及其他病毒的基于磁性、比色、等离子体、电学和侧向流动的芯片实验室技术的发展。我们专注于可大规模部署的快速即时检测技术，因为此类设备有望成为当前逆转录聚合酶链反应（RT-PCR）诊断检测金标准的替代方案。
本综述旨在概述该领域的当前状态，并为创新开发用于COVID-19检测的新型芯片实验室检测方法提供参考资源。
