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壳聚糖及其衍生物的抗菌和抗氧化性能及其应用:综述。

Antimicrobial and antioxidant properties of chitosan and its derivatives and their applications: A review.

机构信息

Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

Department of Agricultural Microbiology, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

出版信息

Int J Biol Macromol. 2020 Dec 1;164:2726-2744. doi: 10.1016/j.ijbiomac.2020.08.153. Epub 2020 Aug 22.

Abstract

In this era, there is a global concern in the use of bioactive molecules such as chitosan in the field of antimicrobial and antioxidant benefits. Because of its biodegradability, biological compatibility, antimicrobial, antioxidants activity, and high safety, chitosan could be used in a large number of applications. It could exist in many forms, such as fibers, gels, films, sponges, nanoparticles, and beads. The different biological activities of chitosan and its products are extensively investigated to broaden the application fields in several areas. Chitosan's natural properties depend strongly on water and other solvent solubility. Consequently, the chitosan oligosaccharides with a low polymerization degree are getting significant attention in the pharmaceutical and medical applications because they have lower viscosity and higher water solubility than chitosan. The objective of this review article is to put the antioxidant and antimicrobial properties of chitosan and its derivatives under the spotlight. The impacts of chitosan on physicochemical parameters like molecular weight and deacetylation degree on its bioactivities are also identified. Additionally, other applications of chitosan and its derivatives, including wound healing products, wastewater treatment, and cosmetics, have also been highlighted.

摘要

在这个时代,人们普遍关注壳聚糖等生物活性分子在抗菌和抗氧化方面的应用。由于其可生物降解性、生物相容性、抗菌性、抗氧化活性和高安全性,壳聚糖可用于大量应用。它可以以纤维、凝胶、薄膜、海绵、纳米粒子和珠粒等多种形式存在。为了拓宽在多个领域的应用范围,人们广泛研究了壳聚糖及其产品的不同生物活性。壳聚糖的天然性质强烈依赖于水和其他溶剂的溶解度。因此,具有低聚合度的壳聚糖低聚糖由于其粘度较低且水溶性较高,在药物和医疗应用中受到了极大的关注。本文的目的是关注壳聚糖及其衍生物的抗氧化和抗菌特性。还确定了壳聚糖的分子量和脱乙酰度等物理化学参数对其生物活性的影响。此外,还强调了壳聚糖及其衍生物的其他应用,包括伤口愈合产品、废水处理和化妆品。

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