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真核生物中驱动蛋白和驱动蛋白相关蛋白的功能。

The functions of kinesin and kinesin-related proteins in eukaryotes.

机构信息

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences , Beijing, China.

The College of Advanced Agricultural Science, The University of Chinese Academy of Sciences , Beijing, China.

出版信息

Cell Adh Migr. 2020 Dec;14(1):139-152. doi: 10.1080/19336918.2020.1810939.

Abstract

Kinesins constitute a superfamily of ATP-driven microtubule motor enzymes that convert the chemical energy of ATP hydrolysis into mechanical work along microtubule tracks. Kinesins are found in all eukaryotic organisms and are essential to all eukaryotic cells, involved in diverse cellular functions such as microtubule dynamics and morphogenesis, chromosome segregation, spindle formation and elongation and transport of organelles. In this review, we explore recently reported functions of kinesins in eukaryotes and compare their specific cargoes in both plant and animal kingdoms to understand the possible roles of uncharacterized motors in a kingdom based on their reported functions in other kingdoms.

摘要

驱动蛋白构成了一个 ATP 驱动的微管马达酶超家族,能够将 ATP 水解的化学能转化为沿着微管轨道的机械功。驱动蛋白存在于所有真核生物中,对所有真核细胞都是必不可少的,参与多种细胞功能,如微管动力学和形态发生、染色体分离、纺锤体形成和伸长以及细胞器的运输。在这篇综述中,我们探讨了最近报道的驱动蛋白在真核生物中的功能,并比较了它们在植物和动物王国中的特定货物,以了解在一个王国中未被描述的马达可能的作用,这是基于它们在其他王国中的报道功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2214/7513868/5b6ca83615cc/KCAM_A_1810939_F0001_OC.jpg

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