Rinsky R A, Ott G, Ward E, Greenberg H, Halperin W, Leet T
National Institute for Occupational Safety and Health, Centers for Disease Control, Cincinnati, Ohio 45226.
Am J Ind Med. 1988;13(4):429-38. doi: 10.1002/ajim.4700130403.
To assess the mortality experience of a cohort of chemical workers in the Kanawha Valley of West Virginia, 29,139 males who worked at any one of three facilities over a 39-year period were followed-up for vital status. The facilities include two chemical manufacturing plants and a research and development center. From this cohort, 5,785 men were found to have died as of the study end, December 31, 1978. This was less than the 6,148.5 men expected to have died, based upon the United States white male population (standardized mortality ratio (SMR) = 94, 95% confidence interval (CI) = 92-96). Eighty-six specific causes of death were examined. Statistically significant increased deaths were observed for two causes; cancers of the liver (not specified as primary or secondary) (SMR = 174; CI = 102-280) and lympho- and reticulosarcoma (SMR = 140; CI = 104-187). When all biliary and liver cancer was examined by duration and time since initial employment, the SMR for those who worked at least 25 years and whose deaths occurred 30 years or more after first employment was 301 (95% confidence limit = 168-497). The identification and follow-up of this complete cohort provides the basis for future study of subcohorts with specific chemical and process exposures and case control studies of specific causes of death.
为评估西弗吉尼亚州卡诺瓦河谷一群化学工人的死亡情况，对在39年期间曾在三个工厂中任何一个工作过的29,139名男性进行了生命状况随访。这些工厂包括两家化学制造工厂和一个研发中心。截至1978年12月31日研究结束时，在这个队列中发现有5,785名男性死亡。这比根据美国白人男性人口预期死亡的6,148.5人要少（标准化死亡比（SMR）= 94，95%置信区间（CI）= 92 - 96）。研究了86种具体死因。观察到有两种死因的死亡人数在统计学上显著增加；未明确为原发性或继发性的肝癌（SMR = 174；CI = 102 - 280）和淋巴肉瘤及网状细胞肉瘤（SMR = 140；CI = 104 - 187）。当按工作时长和首次就业后的时间对所有胆管癌和肝癌进行检查时，那些工作至少25年且死亡发生在首次就业30年或更久之后的人的SMR为301（95%置信限 = 168 - 497）。对这个完整队列的识别和随访为未来对有特定化学物质和工艺暴露的亚队列的研究以及特定死因的病例对照研究提供了基础。
