Rapiti E, Fantini F, Dell'Orco V, Fano V, Blasetti F, Bracci C, Forastiere F, Comba P
Epidemiology Unit, Lazio Region Health Authority, Rome, Italy.
Eur J Epidemiol. 1997 Apr;13(3):281-5. doi: 10.1023/a:1007355519112.
Objective of this study was to assess the mortality experience of a cohort of chemical workers at a plant located in central Italy. Subjects employed for any time between 1954 and 1970 at the chemical plant were included in the cohort and followed up to June 1991. The workers were classified as having ever/never worked in one of the following work processes: organic chemicals, acid mixtures, cleansing agents and insecticides. Mortality experience of the cohort was compared with that of the regional population by computing SMRs (standardized mortality ratios) and 90% CI (confidence intervals). Vital status was ascertained for 96% of the 505 cohort members. All causes of mortality for the entire cohort were lower than expected (Obs: 176; SMR: 0.90; 90% CI: 0.79-1.03). Analysis by work process revealed an increased mortality for lymphatic and hematopoietic tissue neoplasm in the cleansing agents department (Obs: 3; SMR: 5.00; 90% CI: 1.36-12.9); peritoneum and retropertioneum neoplasm in the organic compounds production (Obs: 2; SMR: 13.33; 90% CI: 2.37-42.0), and bladder cancer in the insecticides process (Obs: 3; SMR: 3.53; 90% CI: 0.96-9.12). Although the study had a low statistical power, the increased cancer risks detected are consistent with previous observations and may be of etiologic interest.
本研究的目的是评估意大利中部一家工厂的一群化学工人的死亡情况。该队列纳入了1954年至1970年期间在该化工厂工作过的所有人员，并随访至1991年6月。这些工人被分类为曾在/从未在以下工作流程之一工作过：有机化学品、酸性混合物、清洁剂和杀虫剂。通过计算标准化死亡比（SMR）和90%置信区间（CI），将该队列的死亡情况与该地区人群的死亡情况进行比较。在505名队列成员中，96%的人员的生命状态得以确定。整个队列的所有死因均低于预期（观察值：176；标准化死亡比：0.90；90%置信区间：0.79 - 1.03）。按工作流程分析显示，清洁剂部门淋巴和造血组织肿瘤的死亡率增加（观察值：3；标准化死亡比：5.00；90%置信区间：1.36 - 12.9）；有机化合物生产部门腹膜和腹膜后肿瘤的死亡率增加（观察值：2；标准化死亡比：13.33；90%置信区间：2.37 - 42.0），以及杀虫剂生产流程中膀胱癌的死亡率增加（观察值：3；标准化死亡比：3.53；90%置信区间：0.96 - 9.12）。尽管该研究的统计效力较低，但检测到的癌症风险增加与先前的观察结果一致，可能具有病因学意义。
