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儿童肝母细胞瘤的ALPPS微创一期手术。

A minimally invasive first stage of ALPPS for hepatoblastoma in a child.

作者信息

Akhaladze Dmitry, Uskova Natalia, Rabaev Gavriil, Kachanov Denis, Grachev Nikolay

机构信息

Departments of Oncology and Pediatric Surgery of Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

Department of Clinical Oncology of Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

出版信息

Ann Hepatobiliary Pancreat Surg. 2020 Aug 31;24(3):352-356. doi: 10.14701/ahbps.2020.24.3.352.

DOI:10.14701/ahbps.2020.24.3.352
PMID:32843604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7452797/
Abstract

Large and giant tumors, especially hepatoblastomas, are more frequently presented in pediatric patients. At about two-third of hepatoblastomas at the time of diagnosis are unresectable and liver transplantation is considered as a treatment of choice because of insufficient future liver remnant volume. In selected cases, 2-staged hepatectomy may be the unique chance for curative resection except hepatectomy followed by liver replacement. Despite the overwhelming spread of minimally invasive liver surgery, the laparoscopic approach remains uncommon in children. A case of successful partial associating liver partition with portal vein ligation for staged hepatectomy firstly accomplished pure laparoscopically on the first stage in an infant is presented. Described experience suggests both: the feasibility of laparoscopic procedures and the effectiveness of partial in situ liver splitting to reach appropriate future liver remnant volume and to avoid liver transplantation and its disadvantages.

摘要

大肿瘤和巨大肿瘤,尤其是肝母细胞瘤,在儿科患者中更为常见。在诊断时,约三分之二的肝母细胞瘤无法切除,由于未来肝残余体积不足,肝移植被视为首选治疗方法。在某些选定的病例中,除了肝切除术后进行肝脏置换外,两阶段肝切除术可能是根治性切除的唯一机会。尽管微创肝脏手术广泛普及,但腹腔镜手术在儿童中仍不常见。本文介绍了一例成功的部分联合肝脏分隔与门静脉结扎分期肝切除术,该手术首先在一名婴儿的第一阶段完全通过腹腔镜完成。所描述的经验表明:腹腔镜手术的可行性以及部分原位肝分割达到合适的未来肝残余体积并避免肝移植及其弊端的有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0237/7452797/cb06b6a19473/AHBPS-24-352-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0237/7452797/f3958ae26409/AHBPS-24-352-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0237/7452797/4a39c8cd882d/AHBPS-24-352-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0237/7452797/595a16c42660/AHBPS-24-352-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0237/7452797/cb06b6a19473/AHBPS-24-352-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0237/7452797/f3958ae26409/AHBPS-24-352-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0237/7452797/4a39c8cd882d/AHBPS-24-352-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0237/7452797/595a16c42660/AHBPS-24-352-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0237/7452797/cb06b6a19473/AHBPS-24-352-f4.jpg

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本文引用的文献

1
Segment 7 Laparoscopic Liver Resection: Is It Possible to Resect When Metastatic Lesions Border Suprahepatic Veins?第七部分 腹腔镜肝切除术:当转移病灶位于肝上静脉边界时是否可行切除?
J Gastrointest Surg. 2018 Sep;22(9):1643-1644. doi: 10.1007/s11605-018-3824-8. Epub 2018 May 31.
2
The Southampton Consensus Guidelines for Laparoscopic Liver Surgery: From Indication to Implementation.《南安普敦腹腔镜肝手术共识指南:从适应证到实施》。
Ann Surg. 2018 Jul;268(1):11-18. doi: 10.1097/SLA.0000000000002524.
3
Modified Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy for Hepatoblastoma in a Small Infant: How Far Can We Push the Envelope?
Current trends and prospects of surgical techniques for hepatoblastoma.
肝母细胞瘤的外科技术现状与展望。
Cancer Med. 2024 Jan;13(1):e6795. doi: 10.1002/cam4.6795. Epub 2024 Jan 5.
4
Case report: Portal vein ligation: lessons from patients with PRETEXT III hepatoblastoma in restoring future liver remnant before major hepatectomy and literature review.病例报告:门静脉结扎术:PRETEXT III期肝母细胞瘤患者在大肝切除术前恢复未来肝残余量的经验教训及文献综述
Front Surg. 2023 Jun 19;10:1152901. doi: 10.3389/fsurg.2023.1152901. eCollection 2023.
5
Advances in the conventional clinical treatment for hepatoblastoma and therapeutic innovation.肝母细胞瘤传统临床治疗的进展与治疗创新。
World J Pediatr Surg. 2021 Jun 8;4(3):e000220. doi: 10.1136/wjps-2020-000220. eCollection 2021.
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Recent advances in surgical strategies and liver transplantation for hepatoblastoma.肝母细胞瘤的外科策略和肝移植的最新进展。
Cancer Med. 2023 Feb;12(4):3909-3918. doi: 10.1002/cam4.5300. Epub 2022 Nov 16.
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Evidence on Indications and Techniques to Increase the Future Liver Remnant in Children Undergoing Extended Hepatectomy: A Systematic Review and Meta-Analysis of Individual Patient Data.增加接受扩大肝切除术儿童未来肝残余量的指征和技术的证据:个体患者数据的系统评价和荟萃分析
Front Pediatr. 2022 May 30;10:915642. doi: 10.3389/fped.2022.915642. eCollection 2022.
8
Portal vein embolization in children: As good as ALPPS.儿童门静脉栓塞术:与联合肝脏分隔和门静脉结扎的二步肝切除术效果相当。
Ann Hepatobiliary Pancreat Surg. 2021 May 31;25(2):313-314. doi: 10.14701/ahbps.2021.25.2.313.
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Ann Transl Med. 2016 Oct;4(19):375. doi: 10.21037/atm.2016.10.01.
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An updated systematic review of the evolution of ALPPS and evaluation of its advantages and disadvantages in accordance with current evidence.根据当前证据对联合肝脏分割和门静脉结扎的分期肝切除术(ALPPS)的演变及其优缺点进行的最新系统评价。
Medicine (Baltimore). 2016 Jun;95(24):e3941. doi: 10.1097/MD.0000000000003941.
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First ALPPS procedure using a total robotic approach.首例采用全机器人手术方式的联合肝脏分割和门静脉结扎的分阶段肝切除术(ALPPS)。
Surg Oncol. 2016 Dec;25(4):457. doi: 10.1016/j.suronc.2015.10.001. Epub 2015 Nov 14.
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