Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Int Rev Neurobiol. 2020;155:141-168. doi: 10.1016/bs.irn.2020.02.003. Epub 2020 Aug 11.
Alzheimer's disease (AD) and Parkinson's disease (PD) are, respectively, the most prevalent and fastest growing neurodegenerative diseases worldwide. The former is primarily characterized by memory loss and the latter by the motor symptoms of tremor and bradykinesia. Both AD and PD are progressive diseases that share several key underlying mitochondrial, inflammatory, and other metabolic pathologies. This review will detail how these pathologies intersect with ketone body metabolism and signaling, and how ketone bodies, particularly d-β-hydroxybutyrate (βHB), may serve as a potential adjunctive nutritional therapy for two of the world's most devastating conditions.
阿尔茨海默病（AD）和帕金森病（PD）分别是全球最常见和增长最快的神经退行性疾病。前者的主要特征是记忆力丧失，后者的运动症状是震颤和运动徐缓。AD 和 PD 都是进行性疾病，它们有几个关键的潜在的线粒体、炎症和其他代谢病理学。这篇综述将详细介绍这些病理学如何与酮体代谢和信号转导交叉，以及酮体，特别是 D-β-羟基丁酸（βHB），如何作为世界上两种最具破坏性疾病的潜在辅助营养治疗方法。
