衰老和与年龄相关疾病中的细胞衰老：对神经退行性疾病的影响。
Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases.
机构信息
Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States.
Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States.
出版信息
Int Rev Neurobiol. 2020;155:203-234. doi: 10.1016/bs.irn.2020.03.019. Epub 2020 Aug 11.
Abstract
Aging is the major predictor for developing multiple neurodegenerative diseases, including Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells, which can drive aging phenotypes, accumulate at etiological sites of many age-related chronic diseases. These cells are resistant to apoptosis and can cause local and systemic dysfunction. Decreasing senescent cell abundance using senolytic drugs, agents that selectively target these cells, alleviates neurodegenerative diseases in preclinical models. In this review, we consider roles of senescent cells in neurodegenerative diseases and potential implications of senolytic agents as an innovative treatment.
摘要
衰老是多种神经退行性疾病（包括阿尔茨海默病（AD）和其他痴呆症以及帕金森病（PD））发展的主要预测因素。衰老细胞，可驱动衰老表型，在许多与年龄相关的慢性疾病的病因部位积累。这些细胞对细胞凋亡有抗性，并可导致局部和全身功能障碍。使用选择性靶向这些细胞的衰老细胞裂解药物减少衰老细胞的丰度，可以减轻临床前模型中的神经退行性疾病。在这篇综述中，我们考虑了衰老细胞在神经退行性疾病中的作用以及衰老细胞裂解剂作为一种创新治疗方法的潜在意义。
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