Department of Stomatology, The Third People Hospital of Hainan Province, Sanya, Hainan, China (mainland).
Med Sci Monit. 2020 Aug 29;26:e925735. doi: 10.12659/MSM.925735.
BACKGROUND Head and neck squamous cell carcinoma (HNSC) is an invasive malignancy with a high worldwide mortality, despite considerable recent advancements in diagnosis and treatment. Increasing evidence indicates that the Lamin C (LAMC) gene family is associated with the progression of diverse cancers, nevertheless, this association is not well understood. MATERIAL AND METHODS A systematic study addressing the expression and prognostic value of LAMC, and the relationship between LAMC and tumor immune response in HNSC was done. Finally, we performed drug screening to identify specific drugs. RESULTS Compared to normal samples, expressions of LAMC1 and LAMC2 were significantly increased in HNSC, and LAMC2 was obviously correlated with an adverse prognosis for patients. LAMC2 expression level was significantly correlated with the infiltrating levels of B cells, CD8+ T cells, CD4+ T cells, and macrophages. Moreover, LAMC2 exhibited strong correlations with diverse immune markers, immune microenvironment, and immune checkpoint molecules. Finally, candidate drugs that targeted LAMC2 were identified. CONCLUSIONS This study suggests that LAMC2 could serve as a new prognostic biomarker, and it could be used for efficacy of target for immune response and for drug sensitivity prediction in HNSC.
头颈部鳞状细胞癌（HNSC）是一种具有高全球死亡率的侵袭性恶性肿瘤，尽管最近在诊断和治疗方面取得了相当大的进展。越来越多的证据表明，核纤层蛋白 C（LAMC）基因家族与多种癌症的进展有关，但这种关联尚未得到很好的理解。
系统研究了 LAMC 在 HNSC 中的表达和预后价值，以及 LAMC 与肿瘤免疫反应之间的关系。最后，我们进行了药物筛选，以确定特定的药物。
与正常样本相比，LAMC1 和 LAMC2 在 HNSC 中的表达明显增加，并且 LAMC2 与患者的不良预后明显相关。LAMC2 表达水平与 B 细胞、CD8+T 细胞、CD4+T 细胞和巨噬细胞的浸润水平显著相关。此外，LAMC2 与多种免疫标志物、免疫微环境和免疫检查点分子表现出强烈的相关性。最后，确定了针对 LAMC2 的候选药物。
本研究表明，LAMC2 可以作为一种新的预后生物标志物，可用于预测 HNSC 的免疫反应疗效和药物敏感性。
