Clinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, Room 1349, 131 S. Robertson, Ste 1300, New Orleans, LA, 70112, USA.
Faculty of Biology, Medicine and Health, University of Manchester, A.V. Hill Building, Oxford Road, Manchester, M13 9PT, UK.
Transl Stroke Res. 2021 Feb;12(1):1-14. doi: 10.1007/s12975-020-00841-w. Epub 2020 Aug 29.
Stroke is a major cause of death and disability worldwide. Yet therapeutic strategies available to treat stroke are very limited. There is an urgent need to develop novel therapeutics that can effectively facilitate functional recovery. The injury that results from stroke is known to induce neurogenesis in penumbra of the infarct region. There is considerable interest in harnessing this response for therapeutic purposes. This review summarizes what is currently known about stroke-induced neurogenesis and the factors that have been identified to regulate it. Additionally, some key studies in this field have been highlighted and their implications on future of stroke therapy have been discussed. There is a complex interplay between neuroinflammation and neurogenesis that dictates stroke outcome and possibly recovery. This highlights the need for a better understanding of the neuroinflammatory process and how it affects neurogenesis, as well as the need to identify new mechanisms and potential modulators. Neuroinflammatory processes and their impact on post-stroke repair have therefore also been discussed.
中风是全球范围内主要的死亡和残疾原因。然而，可用于治疗中风的治疗策略非常有限。因此，迫切需要开发新的治疗方法，以有效促进功能恢复。众所周知，中风引起的损伤会在梗塞区域的半影区诱导神经发生。人们对利用这种反应来达到治疗目的非常感兴趣。这篇综述总结了目前关于中风诱导的神经发生以及已经确定的调节因素的知识。此外，还强调了该领域的一些关键研究，并讨论了它们对中风治疗未来的影响。神经炎症和神经发生之间存在复杂的相互作用，决定了中风的结果，可能还决定了恢复情况。这突出表明需要更好地了解神经炎症过程以及它如何影响神经发生，同时还需要确定新的机制和潜在的调节剂。因此，还讨论了神经炎症过程及其对中风后修复的影响。
