基因变异对接受减重手术患者体重的影响：初步探索性研究。
Can the Gene Variant Have an Effect on the Body Weight of Patients Undergoing Bariatric Surgery?-Preliminary, Exploratory Study.
机构信息
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.
Department of Biology, Stephen F. Austin State University, Nacogdoches, TX 75962, USA.
出版信息
Nutrients. 2020 Aug 28;12(9):2621. doi: 10.3390/nu12092621.
BACKGROUND
The gene (Se gene) encoding the enzyme α-1,2-L-fucosyltransferase 2 seems to have a significant effect on the number and type of bacteria colonizing the intestines.
METHODS
In a group of 19 patients after bariatric surgery, the polymorphism (rs601338) of gene was analyzed in combination with body mass reduction, intestinal microbiome (16S RNA sequencing), and short chain fatty acids (SCFA) measurements in stools.
RESULTS
Among the secretors (Se/Se polymorphism of the gene rs601338, carriers of GG variant), correlations between waist-hip ratio (WHR) and propionate content and an increase in , , , and were observed. On the other hand-in non-secretors (carriers of GA and AA variants)-higher abundance of , , , was recorded.
CONCLUSIONS
The increased concentrations of propionate observed among the GG variants of may be used as an additional source of energy for the patient and may have a higher risk of increasing the WHR than carriers of the other variants (GA and AA).
背景
编码酶α-1,2-L-岩藻糖基转移酶 2 的基因（Se 基因）似乎对定植于肠道的细菌数量和类型有显著影响。
方法
在一组接受减肥手术后的 19 名患者中，结合体重减轻、肠道微生物组（16S RNA 测序）和粪便中短链脂肪酸（SCFA）测量，分析了基因的多态性（rs601338）。
结果
在分泌者（基因 rs601338 的 Se/Se 多态性，GG 变异型的携带者）中，观察到腰臀比（WHR）与丙酸盐含量之间存在相关性，并且 、 、 、 增加。另一方面，在非分泌者（GA 和 AA 变异型携带者）中，记录到更高的 、 、 、 的丰度。
结论
在基因 GG 变异型中观察到丙酸盐浓度升高，可能为患者提供额外的能量来源，与其他变异型（GA 和 AA）携带者相比，可能有更高的 WHR 增加风险。
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