Rotake Dinesh, Darji Anand, Kale Nitin
Department of Electronics Engineering, Sardar Vallabhbhai National Institute of Technology, Surat, Gujarat, India.
The Chief Technology Officer, NanoSniff Technologies Pvt. Ltd., F-14, 1st Floor, IITB Research Park, Old CSE Building, IIT Bombay, Powai, Mumbai - 76, India.
Beilstein J Nanotechnol. 2020 Aug 18;11:1242-1253. doi: 10.3762/bjnano.11.108. eCollection 2020.
This paper proposes the selective and ultrasensitive detection of Cd(II) ions using a cysteamine-functionalized microcantilever-based sensor with cross-linked ᴅʟ-glyceraldehyde (DL-GC). The detection time for various laboratory-based techniques is generally 12-24 hours. The experiments were performed to create self-assembled monolayers (SAMs) of cysteamine cross-linked with ᴅʟ-glyceraldehyde on the microcantilever surface to selectively capture the targeted Cd(II). The proposed portable microfluidic platform is able to achieve the detection in 20-23 min with a limit of detection (LOD) of 0.56 ng (2.78 pM), which perfectly describes its excellent performance over other reported techniques. Many researchers used nanoparticle-based sensors for the detection of heavy metal ions, but daily increasing usage and commercialization of nanoparticles are rapidly expanding their deleterious effect on human health and the environment. The proposed technique uses a blend of thin-film and microcantilever (micro-electromechanical systems) technology, which mitigate the disadvantages of the nanoparticle approaches, for the selective detection of Cd(II) with a LOD below the WHO limit of 3 μg/L.
本文提出了一种使用基于半胱胺功能化微悬臂梁的传感器与交联的外消旋甘油醛（DL-GC）对镉（II）离子进行选择性超灵敏检测的方法。各种基于实验室的技术的检测时间通常为12至24小时。进行实验以在微悬臂梁表面形成半胱胺与外消旋甘油醛交联的自组装单分子层（SAMs），以选择性捕获目标镉（II）。所提出的便携式微流控平台能够在20至23分钟内完成检测，检测限（LOD）为0.56纳克（2.78皮摩尔），这完美地体现了其相对于其他已报道技术的卓越性能。许多研究人员使用基于纳米颗粒的传感器来检测重金属离子，但纳米颗粒使用量的日益增加及其商业化正在迅速扩大其对人类健康和环境的有害影响。所提出的技术使用薄膜和微悬臂梁（微机电系统）技术的结合，减轻了纳米颗粒方法的缺点，用于选择性检测镉（II），其检测限低于世界卫生组织规定的3微克/升的限值。
